Meta AnalysisID 4680
补充色氨酸对抑郁障碍的影响：系统评价与Meta分析
CRD42021278725
What are the effects of tryptophan supplementation in individuals diagnosed with depressive disorder?
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Record Fields
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- Meta Analysis Id
- 4680
- Evidence Id
- 13238
- Core Evidence Id
- 13238
- Source Meta Analysis Id
- 4648
- Herb2 Meta Analysis Id
- HBMA004648
- Crd Id
- CRD42021278725
- Title
- Effects of Tryptophan Supplementation on Depressive Disorder: Systematic Review with Meta-Analysis
- Review Question
- What are the effects of tryptophan supplementation in individuals diagnosed with depressive disorder?
- Study Type Included
- Randomized controlled trials and uncontrolled clinical trials that have verified the efficacy of tryptophan supplementation in populations diagnosed with depression. Will be excluded: Narrative, integrative and systematic reviews, editorials, dissertations, theses, and studies that do not fit the outline of this work.
- Condition Being Studied
- Depression is one of the most common and frequent mental disorders nowadays, and its most used conventional treatments involve pharmacological therapy through the use of antidepressants and non-pharmacological treatments such as psychotherapy. However, adjuvant and adherence treatments have been increasingly used as potential therapeutic resources for depression, such as a healthy diet that is able to provide key nutrients for proper brain functioning, for example, tryptophan, an essential amino acid and the main precursor of the happiness hormone, serotonin. The overall objective of this study is to analyze the effects of tryptophan supplementation on depressive disorder. This is a systematic review with meta-analysis of randomized controlled trials, which will be conducted from the construction of search strategies that address the proposed research question: What are the effects of tryptophan supplementation in individuals diagnosed with depressive disorder? based on the structure of the acronym PICO.
- Participant
- People with depression.
- Animal
- Human Disease Modelled
- Intervention
- Isolated tryptophan supplementation.
- Comparator Control
- Placebo or no tryptophan supplementation.
- Main Outcome
- Tryptophan intake is inversely associated with the level of depression in the studied population according to the Beck scale, suggesting the efficacy of higher than usual dosages of tryptophan in the improvement of depressive conditions. Measures of effect Odds ratios
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Depression; Depressive Disorder, Major; Dietary Supplements; Humans; Tryptophan
- Contact
- Lucas de Carvalho Siqueira [email protected]
- Organisational Affiliation
- Centro Universitario de Patos - UNIFIP https://unifip.edu.br/inicio
- Funding Source
- Mr Lucas C. Siqueira. Nutrition student at the University Center of Patos Ms Danilo F. Sousa. Master in Nursing at the University of International Integration of Afro-Brazilian Lusophony Dr Raquel B. Nogueira. PhD in Natural Products and Bioactive Synthetics from the Federal University of Paraíba Dr Tiago. PhD in Natural Products and Bioactive Synthetics from the Federal University of Paraíba
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-24
- Registration Date
- 2021-10-25
- Anticipated Start Date
- 2021-03-03
- Anticipated Completion Date
- 2021-12-03
- Title Cn
- 补充色氨酸对抑郁障碍的影响：系统评价与Meta分析
- Title En
- Effects of Tryptophan Supplementation on Depressive Disorder: Systematic Review with Meta-Analysis
- Bilingual Status
- complete