Meta AnalysisID 4677
胰蛋白酶抑制剂的抗菌作用机制：系统评价和Meta分析方案
CRD42020189069
What are the antibacterial mechanisms of action of trypsin inhibitor peptides or proteins? Therefore, the research question is: P – Rats, Mice, Cell, Bacterial culture I - Administration of peptides or proteins trypsin i
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4677
- Evidence Id
- 13235
- Core Evidence Id
- 13235
- Source Meta Analysis Id
- 4645
- Herb2 Meta Analysis Id
- HBMA004645
- Crd Id
- CRD42020189069
- Title
- Antibacterial action mechanisms of trypsin inhibitors: a protocol for systematic review and meta-analysis
- Review Question
- What are the antibacterial mechanisms of action of trypsin inhibitor peptides or proteins? Therefore, the research question is: P – Rats, Mice, Cell, Bacterial culture I - Administration of peptides or proteins trypsin inhibitors type C - Rats or mice, bacterial cells or cultures treated with other bacterial agents O - Mechanisms of action of peptides or proteins trypsin inhibitor type on bacterial activity S- In vitro (bacterial culture), cell and in vivo experimental studies Context and rationale Mortality rates due to opportunistic infections, due to resistance to antimicrobial drugs, have increased, thus being considered a public health problem. In this context, peptides or proteins trypsin inhibitor type has stood out concerning antibacterial activity in animal studies mainly regarding infectious diseases arising from metabolic or external factors, for example, sepsis. Therefore, this systematic review aims to understand the action mechanisms, mainly involved in the antibacterial activity, to have a coherent and concise perception of the action of peptides or proteins trypsin inhibitor type. The information obtained in the proposed review may assist in the development of other research and disseminate the study of these promising bioactive compounds in advancing the production of safe foods and medicines for the world population.
- Study Type Included
- Inclusion criteria: This review will include controlled studies with separate control groups or with cross-over designs. Exclusion criteria: Case studies or studies without control groups will be excluded.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Rats or mice of both sexes and ages, without restriction of water or diet and in vitro (bacterial culture) studies and in cell. Exclusion criteria: Other types of animals or population.
- Human Disease Modelled
- Infectious disease caused by bacteria, for example, sepsis.
- Intervention
- Inclusion criteria: Studies involving treatment with application of trypsin inhibitor peptides that have a mechanism of action Exclusion criteria: Studies that do not describe the antibacterial action, will be excluded.
- Comparator Control
- Inclusion criteria: In vitro studies (bacterial culture), in cell and in vivo studies with rats and / or mice of both sexes and ages will be included that evaluating the use of peptides or proteins trypsin inhibitor type and discuss the possible action mechanisms of antibacterial action. Exclusion criteria: Other types of animals or population and studies without at least one control group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Mechanisms of antibacterial action of peptides or proteins trypsin inhibitor type. Exclusion criteria: Studies that do not describe of antibacterial action.
- Additional Outcome
- Study Method
- Keyword
- Animals; Anti-Bacterial Agents; Seeds; Trypsin Inhibitors
- Contact
- Amanda Maria de Souza Nascimento [email protected]
- Organisational Affiliation
- Federal University of Rio Grande do Norte https://ufrn.br/
- Funding Source
- No source.
- Other Selection Criteria
- There will be no restriction on languages and year of publication.
- Final Publication
- Same Topic Review
- Not applicable.
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-06-11
- Registration Date
- 2020-08-25
- Anticipated Start Date
- 2020-11-30
- Anticipated Completion Date
- 2021-12-30
- Title Cn
- 胰蛋白酶抑制剂的抗菌作用机制：系统评价和Meta分析方案
- Title En
- Antibacterial action mechanisms of trypsin inhibitors: a protocol for systematic review and meta-analysis
- Bilingual Status
- complete