Meta AnalysisID 4637
尿素治疗不适当抗利尿激素分泌综合征
CRD42021213569
What is the currently available evidence for or against urea for hyponatremia from syndrome of inappropriate antidiuretic hormone secretion?
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Record Fields
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- Meta Analysis Id
- 4637
- Evidence Id
- 13195
- Core Evidence Id
- 13195
- Source Meta Analysis Id
- 4666
- Herb2 Meta Analysis Id
- HBMA004666
- Crd Id
- CRD42021213569
- Title
- Urea for Syndrome of Inappropriate Antidiuretic Hormone Secretion
- Review Question
- What is the currently available evidence for or against urea for hyponatremia from syndrome of inappropriate antidiuretic hormone secretion?
- Study Type Included
- Inclusion criteria: -One of the treatments is oral urea -Patient cohort or subgroup consists of close to 100% hyponatremic patients with a presumed etiology of SIADH -Full-length manuscripts, research letters/brief reports, abstracts/conference proceedings describing original studies (retro- or prospective incl. observational and trial, open and blinded, and case report or series) -Reviews will be searched for references -Any or no comparator -Endpoints: plasma or serum sodium level; osmotic demyelination syndrome; resource use, e.g., length of stay or costs (or component of either) Exclusion criteria: -Language not English, French, or German -One of the treatments is not consist of only (or close to 100%) hyponatremic patients with a presumed etiology of SIADH -Patient cohort or subgroup does not consist of only (or close to 100%) hyponatremic patients with a presumed etiology of SIADH -None of the endpoints match our desired ones - 100% (or near 100%) pediatric patients -Language other than English, French, or German
- Condition Being Studied
- Syndrome of Inappropriate Antidiuretic Hormone Secretion
- Participant
- Patients with acute moderate to severe hyponatremia, defined as a serum sodium of <130 mEq/L, where the etiology is believed to be syndrome of inappropriate antidiuretic hormone secretion (SIADH)
- Animal
- Human Disease Modelled
- Intervention
- Urea
- Comparator Control
- 1) nonpeptide vasopressin receptor antagonists (vaptans); 2) supportive measures (e.g., treating the underlying disease; fluid restriction; sodium administration with or without a loop diuretic; or demeclocycline or lithium)
- Main Outcome
- -Plasma or serum sodium level Measures of effect -Standardized mean difference of sodium level
- Outcome Measure
- Additional Outcome
- -Occurrence of severe adverse events-Occurrence of osmotic demyelination syndrome or other severe adverse events -Resource use, e.g., length of stay or costs (or component of either) -Cost-effectiveness Measures of effect -Relative risk of severe adverse events -Relative risk of osmotic demyelination syndrome -Standardized mean difference of sodium level -Standardized mean difference of costs -Incremental cost-effectiveness ratio
- Study Method
- Intervention, Systematic review
- Keyword
- Bodily Secretions; Humans; Hyponatremia; Inappropriate ADH Syndrome; Urea; Vasopressins
- Contact
- Benjamin Geisler [email protected]
- Organisational Affiliation
- Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University, Munich https://www.ibe.med.uni-muenchen.de/index.html
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Germany
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-09
- Registration Date
- 2021-01-11
- Anticipated Start Date
- 2019-10-10
- Anticipated Completion Date
- 2021-04-30
- Title Cn
- 尿素治疗不适当抗利尿激素分泌综合征
- Title En
- Urea for Syndrome of Inappropriate Antidiuretic Hormone Secretion
- Bilingual Status
- complete