Meta AnalysisID 4612
肠道菌群衍生的三甲胺-N-氧化物与慢性肾脏病患者不良预后相关
CRD42022321968
Chronic kidney disease (CKD) is an important cause of disability and death. Circulating trimethylamine N-oxide（TMAO）concentrations inversely correlate with renal function. Whether TMAO is related to the prognosis of CKD，
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Record Fields
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- Meta Analysis Id
- 4612
- Evidence Id
- 13170
- Core Evidence Id
- 13170
- Source Meta Analysis Id
- 4580
- Herb2 Meta Analysis Id
- HBMA004580
- Crd Id
- CRD42022321968
- Title
- Gut microbiota-derived trimethylamine N-oxide is associated with poor prognosis in patients with chronic kidney disease
- Review Question
- Chronic kidney disease (CKD) is an important cause of disability and death. Circulating trimethylamine N-oxide（TMAO）concentrations inversely correlate with renal function. Whether TMAO is related to the prognosis of CKD，and whether it may be a target for CKD treatment？We will assess the effects of TMAO on the prognosis of CKD and whether reducing TAMO concentrations improves prognosis.
- Study Type Included
- All studies that are not secondary literature are reviewed for compliance with the inclusion criteria.
- Condition Being Studied
- Chronic kidney disease (CKD), which afects 8–16% of adults worldwide, is an important cause of disability and death. Gut microbiota-derived uremic toxins have been implicated in the progression of chronic kidney disease (CKD) due to their promoting adverse pathophysiological changes in the kidneys, including fibrosis , loss of kidney tubular function, and reduction in glomerular filtration rate (GFR). Impaired kidney function seriously affects many aspects of human health.
- Participant
- Adult patients with CKD will be included without restrictions on gender or race. Studies that included pregnant women, participants with any other diseases such as cancer or immune-related disease, or participants who took nephrotoxic drugs were excluded.
- Animal
- Human Disease Modelled
- Intervention
- Higher serum or plasma concentrations of trimethylamine-N-oxide.
- Comparator Control
- Lower serum or plasma concentrations of trimethylamine-N-oxide
- Main Outcome
- Development of heart failure. Association with heart failure severity. Morbidity of heart failure. Mortality.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Keyword
- Gastrointestinal Microbiome; Humans; Methylamines; Prognosis; Renal Insufficiency, Chronic; trimethyloxamine
- Contact
- Yachun Li [email protected]
- Organisational Affiliation
- Dongzhimen Hospital
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-30
- Registration Date
- 2022-04-30
- Anticipated Start Date
- Anticipated Completion Date
- 2024-01-07
- Title Cn
- 肠道菌群衍生的三甲胺-N-氧化物与慢性肾脏病患者不良预后相关
- Title En
- Gut microbiota-derived trimethylamine N-oxide is associated with poor prognosis in patients with chronic kidney disease
- Bilingual Status
- complete