Meta AnalysisID 4611
三甲胺-N-氧化物 (TMAO) 与多种健康结局：观察性研究和孟德尔随机化研究Meta分析的总括性综述
CRD42021284730
The primary objective of this systematic review is to summarize the evidence and evaluate the validity of the associations between TMAO and multiple health outcomes. Furthermore, we will perform update meta-analyses to
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4611
- Evidence Id
- 13169
- Core Evidence Id
- 13169
- Source Meta Analysis Id
- 4578
- Herb2 Meta Analysis Id
- HBMA004578
- Crd Id
- CRD42021284730
- Title
- Trimethylamine-N-oxide (TMAO) and multiple health outcomes: umbrella review of meta-analyses of observational studies and Mendelian randomization studies
- Review Question
- The primary objective of this systematic review is to summarize the evidence and evaluate the validity of the associations between TMAO and multiple health outcomes. Furthermore, we will perform update meta-analyses to assess the association between TMAO concentrations and multiple health outcomes.
- Study Type Included
- Inclusion (umbrella review): meta-analyses. We will include one type of study in the umbrella review: meta-analyses exploring the associations between trimethylamine N-oxide (TMAO) concentrations and any health outcomes in human participants. Exclusion (umbrella review): conference abstracts, interviews, letters, reviews. Inclusion (meta-analyses): case-control (including case-cohort and nested case-control) studies, cohort studies. We include one type of study to perform the updated meta-analyses: observational studies exploring the associations between TMAO concentrations and any health outcomes. Exclusion (meta-analyses): conference abstracts, interviews, letters, reviews and meta-analyses. We will exclude studies that do not present study specific data (relative risks, odds ratios, hazard ratios or 95% confidence intervals).
- Condition Being Studied
- Multiple health-related outcomes: mortality, cardiovascular outcomes (cardiovascular disease, hypertension, stroke, major adverse cardiovascular events and so on), anthropometric variables (blood pressure, body mass index), metabolites and metabolic diseases (lipoprotein cholesterol, triglycerides, c-reactive protein, diabetes mellitus and so on), renal outcomes.
- Participant
- Human participants.
- Animal
- Human Disease Modelled
- Intervention
- Intervention: trimethylamine oxide, trimethylamine N-oxide, trimethylammonium oxide and TMAO.
- Comparator Control
- The comparison is the concentrations of TMAO in cases and their controls.
- Main Outcome
- Incidence of stroke, hypertension, cardiovascular disease, major adverse cardiovascular events, diabetes mellitus, and mortality, blood pressure, body mass index, low/high- density lipoprotein cholesterol, total cholesterol, triglycerides, c-reactive protein, and glomerular filtration rate. Measures of effect Measures of categorical variable relative risks, odds ratios, hazard ratios. Measures of continuous variable: weighed mean difference.
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Epidemiologic, Intervention, Meta-analysis, Review of reviews, Systematic review
- Keyword
- Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Diabetes Mellitus; Genetic Variation; Health Status; Humans; Hypertension; Mendelian Randomization Analysis; Metabolic Diseases; Methylamines; Mortality; Public Health; Treatment Outcome; Trimethylamine; Trimethyloxamine
- Contact
- Doudou Li [email protected]
- Organisational Affiliation
- Zhejiang University http://www.zju.edu.cn/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-12
- Registration Date
- 2021-10-12
- Anticipated Start Date
- 2021-06-01
- Anticipated Completion Date
- 2021-12-01
- Title Cn
- 三甲胺-N-氧化物 (TMAO) 与多种健康结局：观察性研究和孟德尔随机化研究Meta分析的总括性综述
- Title En
- Trimethylamine-N-oxide (TMAO) and multiple health outcomes: umbrella review of meta-analyses of observational studies and Mendelian randomization studies
- Bilingual Status
- complete