Meta AnalysisID 4609
三甲胺-N-氧化物与缺血性卒中风险之间的关系：一项系统评价和剂量-反应Meta分析
CRD42022373779
Is there any difference in serum/plasma trimethylamine-N-oxide concentration between ischemic stroke patients and controls? How are the two related?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4609
- Evidence Id
- 13167
- Core Evidence Id
- 13167
- Source Meta Analysis Id
- 4576
- Herb2 Meta Analysis Id
- HBMA004576
- Crd Id
- CRD42022373779
- Title
- The relationship between trimethylamine-N-oxide and the risk of ischemic stroke: a systematic review and dose-response meta-analysis
- Review Question
- Is there any difference in serum/plasma trimethylamine-N-oxide concentration between ischemic stroke patients and controls? How are the two related?
- Study Type Included
- case-control studies
- Condition Being Studied
- Trimethylamine N-oxide (TMAO) has been recognized as a risk factor for cardiovascular disease. However, the role of TMAO in ischemic stroke remains unclear.Stroke is the leading cause of death and neurological dysfunction worldwide，approximately 87% of stroke events are ischemic strokes，Its high disability and mortality rate seriously affects the quality of life of patients and causes a burden on families and society。
- Participant
- Inclusion: Participants with ischemic stroke (as diagnosed using any recognised diagnostic criteria).
- Animal
- Human Disease Modelled
- Intervention
- serum/plasma trimethylamine-N-oxide concentration
- Comparator Control
- Paired people without ischemic stroke
- Main Outcome
- ischemic stroke Measures of effect
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Brain Ischemia; Humans; Ischemic Stroke; Methylamines; Oxides; trimethylamine
- Contact
- Yong Duan [email protected]
- Organisational Affiliation
- Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University/Yunnan Key Laboratory of Laboratory Medicine/Yunnan Province Clinical Research Center for Laboratory Medicine, Kunming, 650032, China http://www.ydyy.cn/
- Funding Source
- It is funded by National Natural Science Foundation of China :“Study on the mechanism of MiR-551b-3p/MXD3/Twist axis regulating invasion and metastasis of Yunnan Xuanwei lung cancer and the transformation of key molecules as potential new markers Yong Duan（82160407）”and“Study on the effect and mechanism of Linderalactone in the treatment ofYunnan Xuanwei Lung Cancer by activating tumor suppressor BCL6B Ya Li（82160696）”
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-09
- Registration Date
- 2022-11-20
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 三甲胺-N-氧化物与缺血性卒中风险之间的关系：一项系统评价和剂量-反应Meta分析
- Title En
- The relationship between trimethylamine-N-oxide and the risk of ischemic stroke: a systematic review and dose-response meta-analysis
- Bilingual Status
- complete