Meta AnalysisID 460
非发酵槲寄生提取物治疗的癌症患者生存期：系统评价与Meta分析
CRD42021233177
How effective is the treatment with non-fermented mistletoe extracts in prolonging the survival of cancer patients when compared to placebo, standard care or other controls?
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Record Fields
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- Meta Analysis Id
- 460
- Evidence Id
- 9018
- Core Evidence Id
- 9018
- Source Meta Analysis Id
- 436
- Herb2 Meta Analysis Id
- HBMA000436
- Crd Id
- CRD42021233177
- Title
- Survival of cancer patients treated with non-fermented mistletoe extracts: a systematic review and meta-analysis
- Review Question
- How effective is the treatment with non-fermented mistletoe extracts in prolonging the survival of cancer patients when compared to placebo, standard care or other controls?
- Study Type Included
- We will include randomized controlled trials (RCT) and non-randomized studies of interventions (NRSI) which compare one group receiving unfermented mistletoe extracts with one or more control groups and provide a relative effect estimate on the patients’ survival. Individualized treatment is common in mistletoe therapy and usually not assessed in RCT (Kotaska 2004; Kienle and Kiene 2011), but more likely to be realized in NRSI (Sherman, Anderson et al. 2016). We therefore plan to include both, RCT and NRSI, to address internal and external validity, respectively.
- Condition Being Studied
- Cancer is the second leading cause of death, accounting for one in six deaths globally in 2018 (WHO 2020). It is a large group of diseases that can occur in any organ or tissue when cell growth becomes uncontrolled. Lung, breast, prostate, colorectal cancer are the most common types (WHO 2020). The disease burden exerts high physical and emotional strain on individuals and families. There is no cure for cancer and a high demand for complementary and alternative medicine (Horneber, Bueschel et al. 2012; Loquai, Dechent et al. 2017; Kemppainen, Kemppainen et al. 2018).
- Participant
- All cancer patients, including all cancer types, age and sex.
- Animal
- Human Disease Modelled
- Intervention
- Mistletoe extracts (MEs) are prepared as aqueous solutions from the European mistletoe Viscum album L. and can be fermented or unfermented (Bussing 2000). They are frequently used in integrative cancer care (Rostock 2020). The multiple ways how mistletoe affects the immune system have been reviewed elsewhere (Oei, Thronicke et al. 2019). Recently, a systematic review and meta-analysis investigated the effect of fermented MEs (Iscador) on the overall survival of cancer patients (Ostermann, Appelbaum et al. 2020). They included 32 studies with 55 strata and calculated a pooled effect estimate of HR=0.59 (95% confidence interval [0.53;0.65], p<0.0001) in favor of the Iscador treatment compared to control. However, there are unfermented MEs available, including AbnovaViscum, Cefalektin, Helixor, Eurixor, Iscucin, Isorel, and Plenosol and it is currently unknown whether unfermented MEs have a pooled effect estimate on the survival of cancer patients that is similar to the findings of Ostermann et al. (2020). We therefore aim to systematically search studies on the effect of unfermented MEs on the survival of cancer patients and pool the effect estimates by meta-analysis.
- Comparator Control
- Various control groups are possible and may include no active control, usual care, placebo, or treatment with a compound other than mistletoe.
- Main Outcome
- The main outcome is the overall survival (including general and event-free survival). Measures of effect We opt for the hazard ratio (HR) and the corresponding 95 % confidence interval (CI).
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Biological Products; Humans; Mistletoe; Neoplasms; Plant Extracts; Viscum album
- Contact
- Martin Loef [email protected]
- Organisational Affiliation
- CHS-Institute https://chs-institute.org/
- Funding Source
- Verein fuer Krebsforschung
- Other Selection Criteria
- Final Publication
- https://journals.sagepub.com/doi/full/10.1177/15347354221133561
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Germany
- Review Stage
- Review Completed published
- First Submission Date
- 2021-01-26
- Registration Date
- 2021-02-22
- Anticipated Start Date
- 2021-02-01
- Anticipated Completion Date
- 2022-09-01
- Title Cn
- 非发酵槲寄生提取物治疗的癌症患者生存期：系统评价与Meta分析
- Title En
- Survival of cancer patients treated with non-fermented mistletoe extracts: a systematic review and meta-analysis
- Bilingual Status
- complete