Meta AnalysisID 458
围手术期整合癌症护理中使用的天然健康产品：槲寄生提取物、支链氨基酸和益生菌的系统评价与Meta分析方案
CRD42018086168
What is the safety and efficacy evidence for the adjunctive use of select natural health products (NHPs) in cancer patients undergoing surgery?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 458
- Evidence Id
- 9016
- Core Evidence Id
- 9016
- Source Meta Analysis Id
- 434
- Herb2 Meta Analysis Id
- HBMA000434
- Crd Id
- CRD42018086168
- Title
- Natural health products used in integrative cancer care during the peri-operative period: protocol for a systematic review and meta-analysis of mistletoe extract, branched-chain amino acids, and probiotics
- Review Question
- What is the safety and efficacy evidence for the adjunctive use of select natural health products (NHPs) in cancer patients undergoing surgery?
- Study Type Included
- For Efficacy outcomes- randomized controlled trials (RCTs) only. For Adverse Events- RCTs, nonrandomized and quasi-randomized controlled clinical trials, controlled observational cohort and case-control studies.
- Condition Being Studied
- Cancer
- Participant
- We will include all oncology patients undergoing cancer-related surgery.
- Animal
- Human Disease Modelled
- Intervention
- The natural health products (NHPs) below will be included, regardless of route of administration, dose, duration, and formulation (i.e., used alone or in combinations): 1. Probiotics (e.g., Lactobacillus acidophilus and other L. species, Bifidobacteria spp., etc.); 2. Branched-chain amino acids (i.e., Leucine, Isoleucine, Valine); 3. Mistletoe (Viscum album) extracts: all types and preparations.
- Comparator Control
- We will evaluate these interventions compared to placebo, active control, or no adjunctive treatment (i.e., usual care).
- Main Outcome
- Primary outcomes: Survival/ mortality, treatment response, recurrence/ remission, disease progression/ metastasis, and stable disease. Measures of effect Relative risks
- Outcome Measure
- Additional Outcome
- Secondary outcomes: We will also include adverse events, post-operative infections and length of antibiotic use, bleeding, length of hospitalization, quality of life/ performance status, wound healing, pain, weight/ BMI/ arm & waist circumference, fatigue, and other complications (e.g., ascites, edema, pleural effusion, liver failure, flapping tremors, encephalopathy, prothrombin time, intestinal obstruction, ileus, constipation, diarrhea, nausea and vomiting). Cancer biomarkers (e.g., PSA, CEA, etc.), immune cells and inflammatory markers, and albumin and ammonia levels will also be included. Measures of effect Relative risks and mean differences
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Amino Acids, Branched-Chain; Biological Products; Humans; Isoleucine; Leucine; Mistletoe; Neoplasms; Probiotics
- Contact
- Dr. Elise Cogo, ND, MSc, MLIS [email protected]
- Organisational Affiliation
- Patterson Institute for Integrative Oncology Research, Canadian College of Naturopathic Medicine
- Funding Source
- Patterson Institute for Integrative Oncology Research, Canadian College of Naturopathic Medicine Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> No specific funding grant received.
- Other Selection Criteria
- Final Publication
- Cogo E, Elsayed M, Liang V, Cooley K, Guerin C, Psihogios A, Papadogianis P. Are Supplemental Branched-Chain Amino Acids Beneficial During the Oncological Peri-Operative Period: A Systematic Review and Meta-Analysis. Integr Cancer Ther. 2021 Jan-Dec;20:1534735421997551. doi: 10.1177/1534735421997551. Cogo E, Elsayed M, Liang V, Cooley K, Guerin C, Psihogios A, Papadogianis P. Probiotics Evaluation in Oncological Surgery: A Systematic Review of 36 Randomized Controlled Trials Assessing 21 Diverse Formulations. Current Oncology. 2021; 28(6):5192-5214. https://doi.org/10.3390/curroncol28060435 https://journals.sagepub.com/doi/10.1177/1534735421997551
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Completed published
- First Submission Date
- 2018-11-19
- Registration Date
- 2018-12-10
- Anticipated Start Date
- 2018-03-01
- Anticipated Completion Date
- 2021-12-31
- Title Cn
- 围手术期整合癌症护理中使用的天然健康产品：槲寄生提取物、支链氨基酸和益生菌的系统评价与Meta分析方案
- Title En
- Natural health products used in integrative cancer care during the peri-operative period: protocol for a systematic review and meta-analysis of mistletoe extract, branched-chain amino acids, and probiotics
- Bilingual Status
- complete