Meta AnalysisID 4528
低剂量口服茶碱作为附加治疗对COPD患者急性加重的影响：一项系统评价与Meta分析
CRD42020196001
For patients with chronic obstructive pulmonary disease (P), is low-dose oral theophylline as additional treatment (I), compared to usual treatment(C), effective on exacerbations, quality of life, exercise tolerance, and
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Record Fields
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- Meta Analysis Id
- 4528
- Evidence Id
- 13086
- Core Evidence Id
- 13086
- Source Meta Analysis Id
- 4497
- Herb2 Meta Analysis Id
- HBMA004497
- Crd Id
- CRD42020196001
- Title
- Effect of Low-dose Oral Theophylline as Additional Treatment on Exacerbations in Patients with COPD：a systematic review and meta-analysis .
- Review Question
- For patients with chronic obstructive pulmonary disease (P), is low-dose oral theophylline as additional treatment (I), compared to usual treatment(C), effective on exacerbations, quality of life, exercise tolerance, and mortality, etc. (O) ?
- Study Type Included
- Both clinical trials and observational studies will be accepted.
- Condition Being Studied
- Theophylline, the most commonly used methylxanthine，has been used in the treatment of COPD for more than 70 years. Conventionally, oral theophylline has been used as a bronchodilator in COPD, but relatively high blood concentrations (10–20mg/l) are required to to achieve clinical effects and is also associated with side effects.Low-dose theophylline(plasma concentrations of 5–10mg/l) has been shown to reduce corticosteroid insensitivity and have immunomodulatory effects as well as few adverse effects in COPD . However the evidence regarding the effect of low-dose theophylline on exacerbation rates is contradictory.
- Participant
- Patients with chronic obstructive pulmonary disease.
- Animal
- Human Disease Modelled
- Intervention
- Low-dose oral theophylline
- Comparator Control
- Usual treatment of COPD or placebo
- Main Outcome
- Exacerbations:The number and severity of exacerbations. Quality of life: Health-related quality of life. Exercise tolerance: 6-Minute Walk Test (6MWT). mortality: all-cause and respiratory mortality. Measures of effect Exacerbations:relative risks, odds ratios, risk difference, number needed to treat. Quality of life:relative risks, odds ratios, risk difference, number needed to treat. Exercise tolerance:relative risks, odds ratios, risk difference, number needed to treat. mortality: relative risks, odds ratios, risk difference, number needed to treat.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Cost effectiveness, Diagnostic, Epidemiologic, Individual patient data (IPD) meta-analysis, Intervention, Meta-analysis, Methodology, Narrative synthesis, Network meta-analysis, Pre-clinical, Prevention, Prognostic, Prospective meta-analysis (PMA), Review of reviews, Service delivery, Synthesis of qualitative studies, Systematic review
- Keyword
- Humans
- Contact
- Zhuman Du [email protected]
- Organisational Affiliation
- Department of Respiratory Medicine, West China Hospital, Sichuan university
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-06-29
- Registration Date
- 2020-07-30
- Anticipated Start Date
- 2020-07-01
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 低剂量口服茶碱作为附加治疗对COPD患者急性加重的影响：一项系统评价与Meta分析
- Title En
- Effect of Low-dose Oral Theophylline as Additional Treatment on Exacerbations in Patients with COPD：a systematic review and meta-analysis .
- Bilingual Status
- complete