Meta AnalysisID 4516
川芎嗪治疗卒中的疗效与安全性
CRD42020170240
Appraise the available evidence on the potential benefits and harms of Ligustrazine use in stroke
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Record Fields
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- Meta Analysis Id
- 4516
- Evidence Id
- 13074
- Core Evidence Id
- 13074
- Source Meta Analysis Id
- 4485
- Herb2 Meta Analysis Id
- HBMA004485
- Crd Id
- CRD42020170240
- Title
- The efficacy and safety of ligustrazine in stroke.
- Review Question
- Appraise the available evidence on the potential benefits and harms of Ligustrazine use in stroke
- Study Type Included
- Randomized controlled trials.
- Condition Being Studied
- Stroke is a common disorder. It is due either to blockage of an artery in the brain or to bleeding in the brain. To improve the cerebral circulation, ligustrazine can protect the brain injury caused by cerebral ischemia-reperfusion. It also can reduce the injury of neurons and microvascular endothelial cells. This Meta-anlysis is to assess the efficacy and safety of ligustrazine in stroke.
- Participant
- Participants could be of any age, sex or ethnic origin, and patients have to be diagnosed according to recognized criteria of stroke.
- Animal
- Human Disease Modelled
- Intervention
- Interventions using ligustrazine as a main treatment. The combination therapy of Ligustrazine and other interventions compared with the same other interventions alone was also included.
- Comparator Control
- No-treatment, placebo, nonpharmaceutical therapy or regular treatment and nursing.
- Main Outcome
- Course of disease outcome（Effective rate） and adverse events. Measures of effect relative risks, odds ratios, risk difference
- Outcome Measure
- Additional Outcome
- Hemorheology indexes (whole blood viscosity, plasma viscosity, hematocrit, fibrinogen) Measures of effect relative risks, odds ratios, risk difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Humans; Pyrazines; Stroke; tetramethylpyrazine
- Contact
- Renjun Gu [email protected]
- Organisational Affiliation
- Nanjing University of traditional Chinese Medicine
- Funding Source
- NSFC projects Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 81674063
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-20
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-02-18
- Anticipated Completion Date
- 2020-05-31
- Title Cn
- 川芎嗪治疗卒中的疗效与安全性
- Title En
- The efficacy and safety of ligustrazine in stroke.
- Bilingual Status
- complete