Meta AnalysisID 4361
抗性淀粉对实验模型肠道健康的影响：系统评价
CRD42021271287
Does resistant starch consumption improve intestinal health in a healthy animal model compared to those who consumed a standard diet? Context and rationale Resistant starch is defined as a portion of starch that cannot b
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Record Fields
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- Meta Analysis Id
- 4361
- Evidence Id
- 12919
- Core Evidence Id
- 12919
- Source Meta Analysis Id
- 4327
- Herb2 Meta Analysis Id
- HBMA004327
- Crd Id
- CRD42021271287
- Title
- Effect of resistant starch on intestinal health of experimental models: a systematic review
- Review Question
- Does resistant starch consumption improve intestinal health in a healthy animal model compared to those who consumed a standard diet? Context and rationale Resistant starch is defined as a portion of starch that cannot be digested by amylases in the small intestine and passes to the colon to be fermented by microbiota. Its properties are similar to those of soluble fiber which is regarded as a kind of dietary fiber. The fiber fermentation and bacterial production of short chain fatty acids (SCFA) can reduces intestinal pH, inhibits the growth of potentially pathogenic bacterial population and increases the solubility and, therefore, absorption of minerals. The SCFA can increase the proliferation of epithelial cells, which, in return, increase the absorptive surface area, which contributes to the absorption of nutrients. However, it is still unclear if the resistanch starch can impact with these effects on the intestinal health . Hence, the aim of the article review is to explore the interactions between resistant starch, their potential effects on the intestinal bacterial populations, and overall intestinal functionality and gut health. In vivo studies allow the collection and analysis of tissues and organs, making it possible to identify the effects of resistant starch on them, both at the macroscopic, microscopic and gene levels. If such effects are confirmed, the in vivo study, will provide support for future research in the field of human nutrition, thus contributing with new strategies and knowledge for the scientific community, becoming a new tool to promote intestinal health.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group Exclusion criteria: Case studies, cross-over studies, studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Studies conducted with rodents or broilers (all sexes) which investigated the effect of resistant starch consumption on intestinal health parameters and employed control diets for comparison. Exclusion criteria: Uncontrolled studies, in vitro studies, in silico studies, studies conducted with humans, animals diferent than rodents or broilers, animals with natural disease or artificially induced disease (including obesity) as well as studies conducted with offsprings, pregnant and nursing animals, elderly animals, ovariectomized animals, animals that consumed a high fat diet, germ-free animals, studies that utilized interventions besides the resistant starch consumption, such as the use of nutrient or specific food restriction as well as those that did not evaluate the resistant starch consumption or intestinal health.
- Human Disease Modelled
- Intestinal health
- Intervention
- Inclusion criteria: resistant starch consumption Exclusion criteria: resistant starch consumption + other food or nutrient
- Comparator Control
- Inclusion criteria: Standard diet Exclusion criteria: All other control conditions (e.g. diet with modifications, such as high fat diet, high frutose diet, standard diet + other food or nutrient)
- Main Outcome
- Outcome Measure
- Inclusion criteria: alterations in intestinal microbiota, gut functionality, gut morphology (goblet cell, crypts, intestinal villi, enterocytes), production of short chain fatty acid Exclusion criteria: no relevant outcomes about the intestinal health reported
- Additional Outcome
- Study Method
- Keyword
- Animals; Intestines; Resistant Starch; Starch
- Contact
- Marcella Mishima [email protected]
- Organisational Affiliation
- Federal University of Viçosa www.ufv.br
- Funding Source
- There are not funding sources/sponsors.
- Other Selection Criteria
- Exclusion criteria: comments, review, editor's letter, case reports, abstracts, theses, review articles, articles in other language diferente than english, articles published with more than 10 years.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review
- Language
- English
- Country
- Brazil, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-13
- Registration Date
- 2021-11-26
- Anticipated Start Date
- 2021-07-26
- Anticipated Completion Date
- 2021-11-26
- Title Cn
- 抗性淀粉对实验模型肠道健康的影响：系统评价
- Title En
- Effect of resistant starch on intestinal health of experimental models: a systematic review
- Bilingual Status
- complete