Meta AnalysisID 4359
羟乙基淀粉对手术期间内皮糖萼的影响：系统评价和Meta分析
CRD42021258094
Endothelial glycocalyx is important for maintaining the endothelial integrity. Factors during fluid therapy including mode of infusion and type of fluid may exert different effect on the degradation of glycocalyx, indica
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4359
- Evidence Id
- 12917
- Core Evidence Id
- 12917
- Source Meta Analysis Id
- 4326
- Herb2 Meta Analysis Id
- HBMA004326
- Crd Id
- CRD42021258094
- Title
- Influence of hydroxyethyl starch on endothelial glycocalyx during surgery: a systemic review and meta-analysis
- Review Question
- Endothelial glycocalyx is important for maintaining the endothelial integrity. Factors during fluid therapy including mode of infusion and type of fluid may exert different effect on the degradation of glycocalyx, indicating different effect on endothelial integrity.
- Study Type Included
- randomized clinical trial
- Condition Being Studied
- perioperative period
- Participant
- Inclusion criteria: patients undergoing surgery Exclusion criteria: 1. patients with sepsis 2. patients with mass blood loss
- Animal
- Human Disease Modelled
- Intervention
- hydroxyethyl starch
- Comparator Control
- other fluids including albumin and Ringer's solution
- Main Outcome
- Glycocalyx shedding, reflected by increased syndecan-1 or heparan sulfate levels
- Outcome Measure
- Additional Outcome
- tissue oxygen saturation; hemoglobin
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Glycocalyx; Humans; Hydroxyethyl Starch Derivatives; Plasma Substitutes
- Contact
- Zhihong Lu [email protected]
- Organisational Affiliation
- Xijing Hospital
- Funding Source
- National Science Foundation of China (No. 81871028)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-05-30
- Registration Date
- 2021-06-30
- Anticipated Start Date
- 2021-05-31
- Anticipated Completion Date
- 2021-06-30
- Title Cn
- 羟乙基淀粉对手术期间内皮糖萼的影响：系统评价和Meta分析
- Title En
- Influence of hydroxyethyl starch on endothelial glycocalyx during surgery: a systemic review and meta-analysis
- Bilingual Status
- complete