Meta AnalysisID 4358
抗性淀粉对慢性肾脏病进展的影响和安全性：系统评价和Meta分析
CRD42021238286
Whether could chronic kidney disease patients benefit from resistant starch? How do the kidney function or inflammation of chronic kidney disease patients change after taking resistant starch comparing with placebos?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4358
- Evidence Id
- 12916
- Core Evidence Id
- 12916
- Source Meta Analysis Id
- 4325
- Herb2 Meta Analysis Id
- HBMA004325
- Crd Id
- CRD42021238286
- Title
- Effects and Safety of Resistant starch on Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis
- Review Question
- Whether could chronic kidney disease patients benefit from resistant starch? How do the kidney function or inflammation of chronic kidney disease patients change after taking resistant starch comparing with placebos?
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Chronic kidney disease (CKD) is a global disease worthy of attention. In China, the prevalence of CKD among people over 18 years is above 10.8%. Current treatments for CKD mainly focus on the use of ACEI, ARB or the control of some risk factors such as hypertension or diabetes, so it is necessary to develop new treatment methods. Resistant starch is a polymeric carbohydrate that has been shown to reduce plasma urema concentrations in animals models of CKD, but the outcomes are mixed while conducting human studies.
- Participant
- Inclusion criteria: chronic kidney disease patients undergoing hemodialysis. Exclusion criteria: (1) did not report outcomes of interest (2) could not extract or calculate treatment effects sufficiently (3) was not a randomized controlled trial
- Animal
- Human Disease Modelled
- Intervention
- Resistant starch was the main intervention
- Comparator Control
- Placebo was the main exposure
- Main Outcome
- Blood urea nitrogen (BUN) and serum creatinine (Scr) at the unit of mg/dL were the main outcomes. Measures of effect Mean Difference
- Outcome Measure
- Additional Outcome
- The secondary outcomes were Indoxyl sulfate (IS) and C-reactive protein (CRP) at the unit of mg/dL, interleukin (IL)-6 at the unit of pg/mL. Measures of effect Mean Difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Disease Progression; Humans; Renal Insufficiency, Chronic; Resistant Starch
- Contact
- Zixian Yu [email protected]
- Organisational Affiliation
- Guizhou Medical University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-02-21
- Registration Date
- 2021-03-22
- Anticipated Start Date
- 2021-01-15
- Anticipated Completion Date
- 2021-06-01
- Title Cn
- 抗性淀粉对慢性肾脏病进展的影响和安全性：系统评价和Meta分析
- Title En
- Effects and Safety of Resistant starch on Chronic Kidney Disease Progression: A Systematic Review and Meta-Analysis
- Bilingual Status
- complete