Meta AnalysisID 4355
抗性淀粉在儿童和青少年中的耐受性：随机对照试验的系统评价和Meta分析方案
CRD42020191364
What is the tolerability of resistant starches used in healthy or sick pediatrics or adolescents compared to placebo, standard care or alternative diets?
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Record Fields
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- Meta Analysis Id
- 4355
- Evidence Id
- 12913
- Core Evidence Id
- 12913
- Source Meta Analysis Id
- 4322
- Herb2 Meta Analysis Id
- HBMA004322
- Crd Id
- CRD42020191364
- Title
- Tolerability of resistant starch in pediatrics and adolescents: a protocol for a systematic review and meta-analysis of randomized controlled trials
- Review Question
- What is the tolerability of resistant starches used in healthy or sick pediatrics or adolescents compared to placebo, standard care or alternative diets?
- Study Type Included
- Controlled comparison studies will be included.
- Condition Being Studied
- Inflammatory bowel disease (IBD) is a chronic disease that impacts the lives of many individuals worldwide with a continuously expanding prevalence. It is estimated that about 25 percent of IBD patients are diagnosed between childhood and adolescence. Currently, there is no cure for IBD, however the symptoms are treated using: aminosalicylates, immunomodulators, corticosteroids, biologic agents, and dietary changes. Treatment of IBD aims to induce and maintain clinical remission and mucosal healing prevents complications. Dietary fibres, such as resistant starches (RS) are being investigated as a food-based treatment option for patients with IBD. Hence, resistant starches may be used as an adjuvant to conventional IBD therapy. We have chosen to examine the use of any type of RS in pediatrics and adolescents (population to be studied later in a clinical trial) in order to evaluate the tolerability of RS diet-supplementation. Our previous review focused solely on IBD and there was minimal data available in order to make relevant conclusions on the effects of RS supplementation, which is why we have expanded our target population to any individual (healthy or diseased).
- Participant
- Pediatrics or adolescents, healthy or diseased
- Animal
- Human Disease Modelled
- Intervention
- We will be including any type of resistant starch (RS1, RS2, RS3, RS4, or RS5).
- Comparator Control
- The comparator can be either placebo or an alternative diet.
- Main Outcome
- Primary outcome: Tolerability: Measures of effect Gastrointestinal disturbances from fermentation include: Pain, bloating, increased flatulence, nausea, vomiting, > 3 stools a day, consistency of stools with Bristol stool scale Type 6 (unformed) and Type 7 (watery).
- Outcome Measure
- Additional Outcome
- Secondary outcomes Measures of effect Short-chain fatty acid production, stool frequency /consistency
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Adolescent; Child; Humans; Meta-Analysis as Topic; Pediatrics; Randomized Controlled Trials as Topic; Resistant Starch; Systematic Reviews as Topic
- Contact
- Manoj Lalu [email protected]
- Organisational Affiliation
- The Ottawa Hospital Research Institute www.ohri.ca
- Funding Source
- This systematic review was funded by a Genome Canada 2017 Large-Scale Applied Research Microbiome-Based Precision Medicine in Inflammatory Bowel Disease grant. The content is solely the responsibility of the authors and does not necessarily represent the official views of Genome Canada
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-06-09
- Registration Date
- 2020-07-10
- Anticipated Start Date
- 2020-06-02
- Anticipated Completion Date
- 2021-06-01
- Title Cn
- 抗性淀粉在儿童和青少年中的耐受性：随机对照试验的系统评价和Meta分析方案
- Title En
- Tolerability of resistant starch in pediatrics and adolescents: a protocol for a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete