Meta AnalysisID 4330
丹参酮IIA磺酸钠注射液对行经皮冠状动脉介入治疗的急性冠脉综合征患者血管内皮功能及炎症因子的影响：随机临床试验的系统评价和Meta分析
CRD42022364547
This study was designed to systematically review the effects of Sodium Tanshinone IIA Sulfonate Injection (STS) on endothelial function and inflammatory factors in patients with acute coronary syndrome (ACS) treated with
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4330
- Evidence Id
- 12888
- Core Evidence Id
- 12888
- Source Meta Analysis Id
- 4298
- Herb2 Meta Analysis Id
- HBMA004298
- Crd Id
- CRD42022364547
- Title
- Effects of Sodium Tanshinone IIA Sulfonate Injection on Vascular Endothelial Function and Inflammatory Factors in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
- Review Question
- This study was designed to systematically review the effects of Sodium Tanshinone IIA Sulfonate Injection (STS) on endothelial function and inflammatory factors in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI) and to provide a basis for further studies.
- Study Type Included
- Randomized controlled trials (RCT)
- Condition Being Studied
- Acute coronary syndrome (ACS) is a common disease of the cardiovascular system characterized by acute myocardial ischemia caused by disruption of coronary artery plaque and consequent thrombosis-induced severe coronary artery stenosis or occlusion, including acute ST-segment elevation myocardial infarction (STEMI), acute non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA). Percutaneous coronary intervention (PCI) is now a common treatment for ACS, saving dying myocardial cells by opening diseased vessels and restoring myocardial perfusion. However, PCI is an invasive and invasive procedure, which may further damage the vascular endothelium during treatment, leading to increased inflammatory response and in-stent thrombosis, and some patients may experience adverse cardiovascular events that affect the prognosis. An increasing number of controlled clinical studies have found that Sodium Tanshinone IIA Sulfonate Injection (STS) is efficacious in ACS and has improved vascular endothelial function and inflammatory factors. However, Meta-analysis on the effects of STS on endothelial function and inflammatory factors has not been reported. Therefore, we systematically evaluated the effects of STS on vascular endothelial function and inflammatory factors in patients with ACS treated with PCI using meta-analysis.
- Participant
- Patients of any age and sex who meet established diagnostic criteria for ACS undergoing PCI
- Animal
- Human Disease Modelled
- Intervention
- conventional therapy in addition to sodium Tanshinone IIA sulfonate injection
- Comparator Control
- conventional therapy
- Main Outcome
- Endothelial function: (1) brachial artery flow-mediated dilatation (FMD); (2) nitric oxide (NO); (3) endothelin (ET)/endothelin-1 (ET-1); (4) von willebrand factor (vWF); (5) homocysteine (Hcy), etc. Inflammatory factors:(1) high-sensitivity C-reactive protein (hs-CRP); (2) interleukin-6 (IL-6); (3) matrix metalloproteinase-9 (MMP-9); (4) tumor necrosis factor-α (TNF-α), etc.
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Acute Coronary Syndrome; Humans; Percutaneous Coronary Intervention; Phenanthrenes; Randomized Controlled Trials as Topic; tanshinone II A sodium sulfonate
- Contact
- Zunqi Kan [email protected]
- Organisational Affiliation
- Shandong University of Traditional Chinese Medicine
- Funding Source
- This research was supported by the National Key R&D Program Research on the Modernization of Traditional Chinese Medicine Key Special Projects (2017YFC1702700). <h1>Conflicts of interest
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- 2022-09-28
- Anticipated Completion Date
- 2022-12-30
- Title Cn
- 丹参酮IIA磺酸钠注射液对行经皮冠状动脉介入治疗的急性冠脉综合征患者血管内皮功能及炎症因子的影响：随机临床试验的系统评价和Meta分析
- Title En
- Effects of Sodium Tanshinone IIA Sulfonate Injection on Vascular Endothelial Function and Inflammatory Factors in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
- Bilingual Status
- complete