Meta AnalysisID 4328
饮食钠限制对左心室肥厚的影响：随机对照试验的系统评价和Meta分析
CRD42022346108
To investigate the impact of dietary sodium restriction on markers of left ventricular hypertrophy assessed by echocardiography and electrocardiographic voltage criteria.
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Record Fields
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- Meta Analysis Id
- 4328
- Evidence Id
- 12886
- Core Evidence Id
- 12886
- Source Meta Analysis Id
- 4296
- Herb2 Meta Analysis Id
- HBMA004296
- Crd Id
- CRD42022346108
- Title
- Effects of dietary sodium restriction on left ventricular hypertrophy: a systematic review and meta-analysis of randomized controlled trials.
- Review Question
- To investigate the impact of dietary sodium restriction on markers of left ventricular hypertrophy assessed by echocardiography and electrocardiographic voltage criteria.
- Study Type Included
- Randomized controlled trials of parallel or cross-over design comparing low to high/usual sodium intake will be included.
- Condition Being Studied
- Left ventricular hypertrophy (LVH) is a condition defined as an increase in left ventricular mass, secondary to ventricular chamber dilation, wall thickening, or both. LVH represents an established risk factor for cardiovascular events, all-cause and cardiovascular mortality in the general population, as well as in the context of multiple comorbidities (i.e. hypertension, diabetes mellitus, chronic kidney disease, obesity etc.). Various complex mechanisms are involved in its pathogenesis and pathophysiology. Among those, increased sodium intake has been identified as a potential factor. Increased sodium intake has long been associated with higher blood pressure, worsening of proteinuria and increased incidence of cardiovascular events. The World Health Organization has incorporated a recommendation of dietary sodium restriction (defined as <2 g/day sodium or <5 g/day salt) in adults as one of the most cost-effective lifestyle modifications for reducing blood pressure and risk of cardiovascular events (strong recommendation). High sodium intake has been implicated in the development of LVH by increasing pressure overload and cardiomyocyte stretch, but also appears to induce LVH independently of blood pressure increments. Therefore, restricting dietary sodium has been proposed as a potential therapeutic approach for reversing LVH.
- Participant
- 1) Inclusion criteria: We will include clinical trials undertaken in adult individuals, both healthy or with an underlying comorbidity linked with left ventricular hypertrophy (e.g. hypertension) that are randomly allocated to a reduced or to a usual/high salt intake. 2) Exclusion criteria: We will exclude all preclinical studies conducted on animals and clinical studies conducted on children or adolescents.
- Animal
- Human Disease Modelled
- Intervention
- Sodium restriction (i.e. low sodium intake)
- Comparator Control
- High or usual sodium intake
- Main Outcome
- The primary outcome measure is change in echocardiographic parameters of left ventricular hypertrophy, assessed either by left ventricular mass (LVM) (in g) or by left ventricular mass index (LVMI) (in g/m2). Measures of effect Mean difference or standardized mean difference
- Outcome Measure
- Additional Outcome
- Secondary outcomes include changes in electrocardiographic voltage criteria of left ventricular hypertrophy (Sokolow-Lyon, Cornell, RaVL). Measures of effect Mean difference or standardized mean difference
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diet, Sodium-Restricted; Humans; Hypertrophy, Left Ventricular; Randomized Controlled Trials as Topic; Sodium, Dietary
- Contact
- Artemios G. Karagiannidis [email protected]
- Organisational Affiliation
- Aristotle University of Thessaloniki
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Greece
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-13
- Registration Date
- 2022-07-24
- Anticipated Start Date
- 2022-07-15
- Anticipated Completion Date
- 2022-08-31
- Title Cn
- 饮食钠限制对左心室肥厚的影响：随机对照试验的系统评价和Meta分析
- Title En
- Effects of dietary sodium restriction on left ventricular hypertrophy: a systematic review and meta-analysis of randomized controlled trials.
- Bilingual Status
- complete