Meta AnalysisID 4239
硅油在眼内炎手术治疗中的作用：一项系统评价
CRD42022357673
The objectives of our study are to systematically review the current literature to evaluate the role of silicone oil in patients with postoperative endophthalmitis treated with pars plana vitrectomy and silicone oil tamp
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Record Fields
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- Meta Analysis Id
- 4239
- Evidence Id
- 12797
- Core Evidence Id
- 12797
- Source Meta Analysis Id
- 4201
- Herb2 Meta Analysis Id
- HBMA004201
- Crd Id
- CRD42022357673
- Title
- The role of silicone oil in the surgical management of endophthalmitis: a systematic review
- Review Question
- The objectives of our study are to systematically review the current literature to evaluate the role of silicone oil in patients with postoperative endophthalmitis treated with pars plana vitrectomy and silicone oil tamponade. The proposed review will answer the following questions: does silicon oil provide a useful contribution to the control and eradication of infection? Does the use of silicone oil influence the visual recovery and the final visual outcome?
- Study Type Included
- Randomized controlled trials, cross-sectional studies, case series, in vitro experimental studies and case reports published in English language in peer-reviewed journals will be included. Articles published before 1995 will be excluded. No restriction will be placed based on the study location. We will exclude editorials and letters to the editors.
- Condition Being Studied
- Endophthalmitis represents one of the biggest diagnostic and therapeutic challenges in modern ophthalmology. It threatens all forms of intraocular surgery. The Endophthalmitis Vitrectomy Study (EVS) was a randomized clinical trial conducted between 1990 and 1995 that aimed to investigate the role of initial pars plana vitrectomy (PPV) and the benefit of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis. The EVS concluded that early vitrectomy should be recommended only for cases with visual acuity of light perception or lower on presentation; however, with the technical advances in vitrectomy, in the following years, many authors reported better results using a such technique in patients with visual acuity higher than light perception. The 2013 European society of cataract and refractive surgeons' guidelines for the prevention and treatment of endophthalmitis after cataract considered a complete vitrectomy and subsequent injection of intravitreal antibiotics as the “gold standard” treatment for acute postoperative endophthalmitis. Another debated topic is whether a complete PPV should be followed with silicone oil (SO) injection given the higher risk of development of retinal breaks and consecutive retinal detachment after vitreous removal. Interestingly, according to some authors, SO could exert a bacteriostatic activity helping therefore in infection control and preventing the development of reinfection.
- Participant
- We included subjects with post-operative endophthalmitis treated with pars plana vitrectomy and silicone oil tamponade. They will be compared with subjects affected by postoperative endophthalmitis and treated with pars plana vitrectomy and tamponades other than silicon oil. We will include in vitro studies evaluating the antimicrobial activity of silicon oil and cases of endophthalmitis in silicon oil-filled eyes.
- Animal
- Human Disease Modelled
- Intervention
- To be enrolled, subjects should receive pars plana vitrectomy and vitreous tamponade as primary treatment for postoperative endophthalmitis. We will further include in vitro studies evaluating the antimicrobial activity of silicon oil.
- Comparator Control
- The Control group will be formed of subjects with postoperative endophthalmitis treated with pars plana vitrectomy and tamponades other than silicon oil.
- Main Outcome
- Outcomes will be the following: antimicrobial activity of silicone oil, anatomical outcome, visual outcome Measures of effect In-vitro experimental studies, bacterial growth was considered in terms of Colony-forming unit (CFU) or with the onset of inhibition halo. The anatomical outcome will be the percentage of retinal detachment, appearance of retinal atrophy, intravitreal injection rate, inflammation control and evisceration rate. The visual outcome will be identified as best-corrected visual acuity improvements.
- Outcome Measure
- Additional Outcome
- Inhibitory activity of different types of silicon olis. Measures of effect Bacterial growth was considered in terms of Colony-forming unit (CFU) or with the onset of inhibition halo
- Study Method
- Intervention, Systematic review
- Keyword
- Endophthalmitis; Humans; Silicone Oils; Vitrectomy
- Contact
- Pasquale Loiudice [email protected]
- Organisational Affiliation
- Pisa University
- Funding Source
- No funding or sponsor. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> NO grant
- Other Selection Criteria
- Final Publication
- Same Topic Review
- No previously registered review.
- Published Protocol
- Review Type
- Language
- English
- Country
- Italy
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-09-02
- Registration Date
- 2022-09-13
- Anticipated Start Date
- 2022-09-13
- Anticipated Completion Date
- 2022-11-02
- Title Cn
- 硅油在眼内炎手术治疗中的作用：一项系统评价
- Title En
- The role of silicone oil in the surgical management of endophthalmitis: a systematic review
- Bilingual Status
- complete