Meta AnalysisID 4058
苯暴露与其相关慢性炎症及免疫抑制关联的系统评价方案
CRD42019138611
Is there scientific evidence of chronic inflammation and immunosuppression associated with benzene exposure?
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Record Fields
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- Meta Analysis Id
- 4058
- Evidence Id
- 12616
- Core Evidence Id
- 12616
- Source Meta Analysis Id
- 4017
- Herb2 Meta Analysis Id
- HBMA004017
- Crd Id
- CRD42019138611
- Title
- Protocol for a systematic review on benzene exposure and its association with chronic inflammation and immunosuppression
- Review Question
- Is there scientific evidence of chronic inflammation and immunosuppression associated with benzene exposure?
- Study Type Included
- Eligible human studies will include epidemiological studies such as case-control, cohort, and, cross-sectional studies as well as descriptive studies (i.e. case studies, case reports, or outcome studies). We will also include all available animal studies, using mammals, with benzene as the agent under review. Since the toxicity of benzene has been related to its metabolism, we will include in vitro studies of human cells exposed to benzene and/or six major active metabolites of benzene: benzene oxide (BO), hydroquinone (HQ), catechol (CAT), 1, 2, 4-benzenetriol (BT), muconaldehyde (MA), and S-phenylmercapturic acid (SPMA).
- Condition Being Studied
- Due to the substantial evidence of human exposure and its carcinogenicity, benzene remains a critical environmental health concern. Thus, it is essential to study the mechanisms of how benzene can cause blood cancers, such as leukemias and lymphomas, to better understand benzene-induced carcinogenesis. This review aims to focus on chronic inflammation and immunosuppression, two outcomes that have never been independently systematically reviewed in relation to benzene. The 2017 IARC Working Group concluded that benzene shows strong evidence of immunosuppression but did not draw a conclusion on whether benzene induced chronic inflammation. With the application of a systematic review approach and a broader, more in-depth, and up-to-date analysis, it is likely that new evidence may be available and that conclusions regarding the evidence of chronic inflammation and immunosuppression in association with benzene could change, since the latest IARC update. Thus, a full systematic review to examine all available mechanistic literature concerning benzene and its link to chronic inflammation and immunosuppression will be useful to guide further studies.
- Participant
- In order to cover the full scope of benzene toxicological studies conducted and to develop a comprehensive understanding of benzene’s effect on immunosuppression and chronic inflammation, we will examine human studies, experimental animal studies (mammals only), and in vitro studies of human cells.
- Animal
- Human Disease Modelled
- Intervention
- The reviewed exposure will be any level of benzene exposure. For in vitro studies, exposure to benzene or 6 major benzene metabolites: benzene oxide, HQ, CAT, BT, MA, SPMA will be reviewed.
- Comparator Control
- Main Outcome
- Only studies that report the presence of immunosuppressive or chronic inflammatory endpoints will be included. In order to determine the prevalence of health outcomes that may be categorized as either immunosuppressive or chronically inflammatory, we will use the following definitions: chronic inflammation is “elevated white blood cells, myeloperoxidase activity, altered cytokine and/or chemokine production” and immunosuppression as defined as “decreased immunosurveillance, immune system dysfunction”. Measures of effect None
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Benzene; Humans; Immune Tolerance; Immunologic Deficiency Syndromes; Immunosuppression; Inflammation
- Contact
- Helen Guo [email protected]
- Organisational Affiliation
- University of California, Berkeley - School of Public Health
- Funding Source
- This project is partially supported by an Undergraduate Faculty Research Grant from the Society of Toxicology. HG is an undergrad trainee of the Berkeley Superfund Research Program (SRP)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-06-11
- Registration Date
- 2019-08-13
- Anticipated Start Date
- 2019-06-11
- Anticipated Completion Date
- 2019-09-06
- Title Cn
- 苯暴露与其相关慢性炎症及免疫抑制关联的系统评价方案
- Title En
- Protocol for a systematic review on benzene exposure and its association with chronic inflammation and immunosuppression
- Bilingual Status
- complete