Meta AnalysisID 405
盐摄入与健康结局：系统评价
CRD42022312482
What is the impact of dietary patterns higher in salt versus diets lower in salt on the risk of patient-important outcomes (e.g. all-cause and cardiovascular mortality, cancer, renal function,, cardiovascular outcomes, a
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 405
- Evidence Id
- 8963
- Core Evidence Id
- 8963
- Source Meta Analysis Id
- 385
- Herb2 Meta Analysis Id
- HBMA000385
- Crd Id
- CRD42022312482
- Title
- Salt intake and health outcomes: a systematic review
- Review Question
- What is the impact of dietary patterns higher in salt versus diets lower in salt on the risk of patient-important outcomes (e.g. all-cause and cardiovascular mortality, cancer, renal function,, cardiovascular outcomes, and quality of life）and on factors that may be causally related to cardiovascular outcomes (e.g. hypertension) among adult patients and community members?
- Study Type Included
- Our research will include both cohort studies and randomized controlled trials. We will not consider other study designs (e.g. case-control study, case series, or cross-sectional studies).
- Condition Being Studied
- Excessive salt intake has been reported to be associated with adverse health outcomes related to cardiovascular health, cancer, and renal diseases (Mente et al. 2014; Neal et al. 2021; Wu et al. 2021; McMahon et al. 2021). However, heterogeneity across subgroups, e.g. on comorbidities and salt-sensitivity, might warrant an individual approach for limiting salt consumption. This study will conduct a structured assessment of the available evidence, including an assessment of quality of evidence of the studies and a dose-response analysis to clarify the association between salt intake and important health-related outcomes.
- Participant
- Inclusion criteria: Adults (>18 years old); with or without cardiometabolic risk factors (e.g. hypertension, obesity, coronary artery disease). Studies with more than 20% of the sample pregnant women will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- Salt-restriction or dietary patterns lower in salt
- Comparator Control
- Inclusion criteria: No restriction in salt consumption or dietary patterns higher in salt (consumption of pickled products e.g. sauerkraut, bacon). If studies compare intake of multiple substances at the same time and only give combined results in a ratio (e.g. sodium-potassium ratio), we will not consider them for our analyses.
- Main Outcome
- All-cause mortality Cardiovascular mortality Blood pressure
- Outcome Measure
- Additional Outcome
- Cancer, weight, bone mineral density, quality of life, satisfaction with diet, type II diabetes, incidence of chronic kidney disease, end-stage kidney disease, or onset of dialysis, cardiovascular outcomes (fatal and non-fatal coronary heart disease, non-fatal stroke, non-fatal myocardial infarction, major adverse cardiac events (MACE), hypertension.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Adult; Carcinoma, Renal Cell; Diet; Humans; Hypertension; Kidney Neoplasms; Quality of Life; Sodium Chloride; Sodium Chloride, Dietary
- Contact
- Robin W.M. Vernooij [email protected]
- Organisational Affiliation
- Utrecht University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Sodium restriction; Protein restriction; Dose-response analysis; Cancer; Chronic kidney disease; Diabetes; Hypertension; Obesity; Cardiovascular risk.
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada, China, Netherlands
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-12-18
- Registration Date
- 2022-12-29
- Anticipated Start Date
- 2023-01-02
- Anticipated Completion Date
- 2024-01-01
- Title Cn
- 盐摄入与健康结局：系统评价
- Title En
- Salt intake and health outcomes: a systematic review
- Bilingual Status
- complete