Meta AnalysisID 4049
大黄联合胰蛋白酶抑制剂治疗重症急性胰腺炎：系统评价与Meta分析
CRD42018087083
To evaluate the efficacy and safety of rhubarb combined with a trypsin inhibitor for severe acute pancreatitis (SAP).
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Record Fields
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- Meta Analysis Id
- 4049
- Evidence Id
- 12607
- Core Evidence Id
- 12607
- Source Meta Analysis Id
- 4009
- Herb2 Meta Analysis Id
- HBMA004009
- Crd Id
- CRD42018087083
- Title
- Rhubarb combined with trypsin inhibitor for severe acute pancreatitis: a systematic review and meta-analysis
- Review Question
- To evaluate the efficacy and safety of rhubarb combined with a trypsin inhibitor for severe acute pancreatitis (SAP).
- Study Type Included
- Inclusion: (1) Randomized controlled trials (RCTs); (2) Studies including patients diagnosed as having severe acute pancreatitis, based on generally accepted criteria; (3) Studies in which rhubarb has been combined with an essential therapy, and compared with the essential therapy as a control; (4) Outcome measurements: mortality, overall efficacy, length of hospitalization, rate of complications, abdominal pain relief time, first defecation time, and serum amylase levels. Exclusion: (1) Reviews, non-clinical studies, non-RCTs and case observation studies; (2) Controlled interventions involving other TCM therapies such as Chinese herbs or acupuncture.
- Condition Being Studied
- Severe acute pancreatitis, as treated using rhubarb combined with trypsin inhibitor.
- Participant
- Patients diagnosed as having severe acute pancreatitis, based on generally accepted criteria.
- Animal
- Human Disease Modelled
- Intervention
- The administration of rhubarb combined with trypsin inhibitor, including somatostatin, ulinastatin, stilamin, and octreotide.
- Comparator Control
- Control: trypsin inhibitor administration only (including somatostatin, ulinastatin, stilamin, and octreotide).
- Main Outcome
- Mortality; The overall efficacy of the treatment. Measures of effect Both outcomes are dichotomous variables, and will be presented using odds ratio (OR) assessments, with 95% confidence intervals (95% CI).
- Outcome Measure
- Additional Outcome
- Length of hospitalization, rate of complications, abdominal pain relief time, first defecation time, and serum amylase levels. Measures of effect All outcomes are continuous variables, and will be presented as mean differences (MD), with 95% confidence intervals (95% CI).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Drug Combinations; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Octreotide; Pancreatitis; Pancreatitis, Acute Necrotizing; Rheum; Somatostatin; Treatment Outcome; Trypsin; Trypsin Inhibitors
- Contact
- Jing Hu [email protected]
- Organisational Affiliation
- Fuxing Hospital https://www.bj-fxh.com/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Simplified, English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-01-27
- Registration Date
- 2018-01-31
- Anticipated Start Date
- 2017-11-25
- Anticipated Completion Date
- 2018-03-25
- Title Cn
- 大黄联合胰蛋白酶抑制剂治疗重症急性胰腺炎：系统评价与Meta分析
- Title En
- Rhubarb combined with trypsin inhibitor for severe acute pancreatitis: a systematic review and meta-analysis
- Bilingual Status
- complete