Meta AnalysisID 4044
妊娠期使用奎宁的安全性（重点聚焦孕早期）：系统评价
CRD42021220789
To describe the toxicity of quinine on the fetus when used in pregnancy.
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Record Fields
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- Meta Analysis Id
- 4044
- Evidence Id
- 12602
- Core Evidence Id
- 12602
- Source Meta Analysis Id
- 4004
- Herb2 Meta Analysis Id
- HBMA004004
- Crd Id
- CRD42021220789
- Title
- Safety of quinine in pregnancy with a focus on first trimester use: a systematic review
- Review Question
- To describe the toxicity of quinine on the fetus when used in pregnancy.
- Study Type Included
- Articles either from malaria endemic and non-malaria endemic countries will be included. Articles on quinine used for any purposes will be included. Case reports or case series will be included. Animal studies will not be included. Articles without pregnancy outcomes will also be excluded.
- Condition Being Studied
- Quinine, safety, pregnancy, fetal, congenital abnormality.
- Participant
- Inclusion: pregnant women who have been treated with quinine irrespective of trimesters, but with a strong intention to discern gestation of ingestion, diseases, and intentions of use. Exclusion: non-pregnant patients.
- Animal
- Human Disease Modelled
- Intervention
- Quinine: either given orally or parenterally.
- Comparator Control
- Women not exposed to quinine during pregnancy.
- Main Outcome
- Congenital abnormalities among fetuses whose mothers have been treated with quinine in any trimesters during pregnancy. The time of exposure: the primary interest is the events after exposures to quinine in the first trimester. Measures of effect Proportion, relative risk or risk difference.
- Outcome Measure
- Additional Outcome
- Miscarriage and stillbirth after quinine exposure in pregnancy. Measures of effect Proportion, relative risk or risk difference.
- Study Method
- Epidemiologic, Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Female; Humans; Pregnancy; Quinine
- Contact
- Makoto Saito [email protected]
- Organisational Affiliation
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand https://www.shoklo-unit.com/
- Funding Source
- SMRU is part of the Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme funded by the Wellcome Trust of Great Britain
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Thailand
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-14
- Registration Date
- 2021-01-18
- Anticipated Start Date
- 2020-11-16
- Anticipated Completion Date
- 2021-03-31
- Title Cn
- 妊娠期使用奎宁的安全性（重点聚焦孕早期）：系统评价
- Title En
- Safety of quinine in pregnancy with a focus on first trimester use: a systematic review
- Bilingual Status
- complete