Meta AnalysisID 4043
氯喹、羟氯喹及奎宁在临床和体内研究中对病毒感染的作用：系统评价与Meta分析
CRD42020183429
Have chloroquine, hydroxychloroquine or quinine shown consistent beneficial effects on survival, organ injury, viral clearance or other biologic markers during viral infection in published clinical and in vivo animal stu
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 4043
- Evidence Id
- 12601
- Core Evidence Id
- 12601
- Source Meta Analysis Id
- 4003
- Herb2 Meta Analysis Id
- HBMA004003
- Crd Id
- CRD42020183429
- Title
- Effects of chloroquine, hydroxychloroquine and quinine in viral infection in clinical and in vivo studies: a systematic review and meta-analysis
- Review Question
- Have chloroquine, hydroxychloroquine or quinine shown consistent beneficial effects on survival, organ injury, viral clearance or other biologic markers during viral infection in published clinical and in vivo animal studies?
- Study Type Included
- Published clinical and in vivo animal studies that compared the effects of chloroquine, hydroxychloroquine or quinine to a control group on survival, organ injury, viral clearance or other biologic markers during viral infection.
- Condition Being Studied
- Chloroquine, hydroxychloroquine and quinine have been used as anti-infective therapies for malaria and as anti-inflammatory therapies for rheumatoid arthritis and several other connective tissue diseases. These agents have been strongly recommended for use in patients during the COVID-19 outbreak but reports are beginning to emerge regarding their adverse and harmful effects. The goal of the present systematic review and analysis is to determine how strong prior published evidence was in patients and in in vivo animal models suggesting that these agents would have beneficial anti-viral effects during COVID-19 infection.
- Participant
- Patients or animals with natural viral infection or receiving a viral challenge of any type treated with chloroquine, hydroxychloroquine or quinine or control and in which the effects of these treatments on survival, organ injury, viral clearance or other biologic markers were assessed.
- Animal
- Human Disease Modelled
- Intervention
- Reports will be retrieved and examined that compared intervention with chloroquine, hydroxychloroquine or quinine versus a control material during viral infection in patients or animals.
- Comparator Control
- Placebo or diluent/carrier for the animal studies
- Main Outcome
- Survival with natural viral infection or following a viral challenge as defined in each retrieved report. If multiple survival outcomes are provided, the one of longest duration will be included in analysis. Measures of effect Relative Risk
- Outcome Measure
- Additional Outcome
- 1. Organ injury 2. Viral clearance 3. Other biologic markers Measures of effect Relative Risk
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Chloroquine; COVID-19; Humans; Hydroxychloroquine; Quinine; Virus Diseases
- Contact
- Parizad Torabi-Parizi [email protected]
- Organisational Affiliation
- National Institutes of Health
- Funding Source
- Intramural research funding from the Clinical Center, National Institutes of Health Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-04-30
- Registration Date
- 2020-05-01
- Anticipated Start Date
- 2020-04-24
- Anticipated Completion Date
- 2020-07-01
- Title Cn
- 氯喹、羟氯喹及奎宁在临床和体内研究中对病毒感染的作用：系统评价与Meta分析
- Title En
- Effects of chloroquine, hydroxychloroquine and quinine in viral infection in clinical and in vivo studies: a systematic review and meta-analysis
- Bilingual Status
- complete