Meta AnalysisID 4028
补骨脂素长波紫外线与窄谱中波紫外线光疗治疗早期蕈样肉芽肿：一项系统评价与Meta分析
CRD42018092733
To investigate the relative efficacy and risks associated with narrowband ultraviolet B (NB-UVB) versus psoralen-ultraviolet A (PUVA) for early-stage mycosis fungoides (MF).
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Record Fields
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- Meta Analysis Id
- 4028
- Evidence Id
- 12586
- Core Evidence Id
- 12586
- Source Meta Analysis Id
- 3986
- Herb2 Meta Analysis Id
- HBMA003986
- Crd Id
- CRD42018092733
- Title
- Psoralen ultraviolet A versus narrowband ultraviolet B phototherapy for early-stage mycosis fungoides: a systematic review and meta-analysis
- Review Question
- To investigate the relative efficacy and risks associated with narrowband ultraviolet B (NB-UVB) versus psoralen-ultraviolet A (PUVA) for early-stage mycosis fungoides (MF).
- Study Type Included
- Comparative studies, in the form of retrospective observational studies, prospective observational studies, matched studies or randomized controlled studies. Single arm studies or non-comparative studies were excluded. Case reports, abstract studies are also excluded.
- Condition Being Studied
- Mycosis fungoides (MF) is a form of cutaneous T-cell lymphoma, characterised in early stages with patches which can progress to generalized plaques, tumors, lymph node and visceral involvement. There are various treatment options for MF including skin-directed agents such as corticosteroids, chemotherapy, radiotherapy and phototherapy-based approaches. Various forms of phototherapy have been used for MF with effective outcomes, although the main forms prescribed include narrowband ultraviolet B (NB-UVB) and psoralen-ultraviolet A (PUVA). Although both have been widely used over the past several decades, there has mainly small-volume non-comparative data to evaluate their efficacy and effectiveness in inducing disease response in early-stage MF.
- Participant
- Inclusion criteria were: cohorts with early-stage MF with biopsy or histological diagnosis, comparative studies comparing PUVA (bath or oral) versus narrowband UVB, at least 10 patients in each comparator group, and reporting outcomes of response to therapy. Exclusion criteria were: paediatric cases, studies with fewer than 10 cases in each comparator group, non-comparative studies, case reports, abstract studies, and case reports.
- Animal
- Human Disease Modelled
- Intervention
- The intervention is PUVA (with psoralen either oral or bath form) in patients with early-stage MF.
- Comparator Control
- The comparator is NB-UVB treatment in patients with early-stage MF.
- Main Outcome
- Response rate.
- Outcome Measure
- Additional Outcome
- Complete response rate. Partial response rate. Failure rate. Relapse-free interval. Adverse outcomes .
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Ficusin; Humans; Mycosis Fungoides; Phototherapy; Skin; Skin Neoplasms; Treatment Outcome; Ultraviolet Therapy
- Contact
- Kevin Phan [email protected]
- Organisational Affiliation
- Liverpool Hospital
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-04-01
- Registration Date
- 2018-04-11
- Anticipated Start Date
- 2018-03-03
- Anticipated Completion Date
- 2018-05-01
- Title Cn
- 补骨脂素长波紫外线与窄谱中波紫外线光疗治疗早期蕈样肉芽肿：一项系统评价与Meta分析
- Title En
- Psoralen ultraviolet A versus narrowband ultraviolet B phototherapy for early-stage mycosis fungoides: a systematic review and meta-analysis
- Bilingual Status
- complete