Meta AnalysisID 3938
原花青素对血压的影响：随机对照试验的系统评价和Meta分析
CRD42020202958
Hypertension a common chronic disease that can lead to serious health problems, such as cardiovascular diseases, diabetes and stroke. Previous studies have not drawn a consistent conclusion about effect of proanthocyanid
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Record Fields
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- Meta Analysis Id
- 3938
- Evidence Id
- 12496
- Core Evidence Id
- 12496
- Source Meta Analysis Id
- 3897
- Herb2 Meta Analysis Id
- HBMA003897
- Crd Id
- CRD42020202958
- Title
- Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials
- Review Question
- Hypertension a common chronic disease that can lead to serious health problems, such as cardiovascular diseases, diabetes and stroke. Previous studies have not drawn a consistent conclusion about effect of proanthocyanidins on blood pressure. This systematic review and meta-analysis aimed to evaluate the effect of proanthocyanidins on blood pressure.
- Study Type Included
- randomized controlled trials
- Condition Being Studied
- Cardiovascular diseases (CVD) present, nowadays, the main burden on healthcare systems worldwide, especially in the developing world. According to the World Health Organization survey, CVD is also the major leading cause of death in the world, accounting for 17.7 million deaths annually, the number that is expected to rise to nearly 23.6 million by 2030. Hypertension is a common chronic disease that can lead to cardiovascular disease and increase risk for other diseases. Therefore, prevention and treatment of hypertension are particularly important for improving the quality of life of the population. Since pharmacological treatments always have a consequence of side effects, nutrition intervention in the treatment of diseases is getting more and more attention.In non-hypertensive and prehypertensive adults, dietary intervention could be considered as an effective approach to prevent hypertension and related complications and reduce the incidence of mortality and morbidity from cardiovascular diseases.
- Participant
- First, studies were imported into End-Note software, version X9 and duplicate publications were removed. Then, two authors(JQA and HYY) reviewed remained manuscripts separately by reading title, abstract or full text. Finally, original studies were included if they met the following inclusion criteria: (i) study design: randomized controlled clinical trials, (ii) intervention: proanthocyanidins supplementation, (iii) population: adult participants(age≥18 years), (iv) measured outcomes: systolic blood pressure (SBP) and diastolic blood pressure (DBP). Exclusion criteria were: (i) treatment duration less than 2 weeks, (ii) without any comparing control group, (iii) lack of sufficient data. During the study selection process, any differences of opinion between authors were resolved by discussion with a third authors (JYR).
- Animal
- Human Disease Modelled
- Intervention
- intervention: proanthocyanidins supplementation; SBP, DBP, MAP and PP.
- Comparator Control
- Intervention group：A group of participants who take a certain dose of proanthocyanidins every day; Placebo group:A group of participants who take placebo tablets every day.
- Main Outcome
- The effect of proanthocyanidins on blood pressure(SBP, DBP, MAP and PP). Measures of effect weighted mean difference
- Outcome Measure
- Additional Outcome
- sensitivity analyses, subgroup analyses, Meta-regression analysis and Publication bias. Measures of effect weighted mean difference
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Blood Pressure; Dietary Supplements; Humans; Proanthocyanidins; Randomized Controlled Trials as Topic
- Contact
- Yuxia Ma [email protected]
- Organisational Affiliation
- Hebei Medical University
- Funding Source
- National Natural Science Foundation of China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> No.81874264
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-15
- Registration Date
- 2020-09-15
- Anticipated Start Date
- 2020-08-03
- Anticipated Completion Date
- 2020-10-01
- Title Cn
- 原花青素对血压的影响：随机对照试验的系统评价和Meta分析
- Title En
- Effect of proanthocyanidins on blood pressure: A systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete