Meta AnalysisID 3931
钾离子竞争性酸阻滞剂治疗非甾体抗炎药所致胃溃疡的疗效与安全性：一项系统评价和Meta分析
CRD42022369695
How is the efficacy and safety of potassium competitive acid blocker in NSAID-induced gastric ulcer disease?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3931
- Evidence Id
- 12489
- Core Evidence Id
- 12489
- Source Meta Analysis Id
- 3890
- Herb2 Meta Analysis Id
- HBMA003890
- Crd Id
- CRD42022369695
- Title
- The efficacy and safety of potassium competitive acid blocker (PCAB) in NSAID-induced gastric ulcer disease: a systematic review and meta-analysis
- Review Question
- How is the efficacy and safety of potassium competitive acid blocker in NSAID-induced gastric ulcer disease?
- Study Type Included
- Only randomized controlled trials will be included in this review.
- Condition Being Studied
- Since 2015, the use of PCAB compared to PPI has been studied for the treatment of NSAID-induced gastric ulcer disease. We aim to summarize and confirm the efficacy and safety of PCAB to PPIs for NSAID-induced gastric ulcer disease in hopes of recommending that PCAB could be an alternative first-line therapy in such conditions.
- Participant
- Patients with NSAID-induced gastric ulcer disease.
- Animal
- Human Disease Modelled
- Intervention
- Any potassium competitive acid blocker including, but not limited to: vonoprazan, soraprazan, revaprazan and linaprazan.
- Comparator Control
- The placebo and proton pump inhibitor including omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole, dexlansoprazole and ilaprazole.
- Main Outcome
- - Improvement in GI symptoms - Healing rate (proportion) of ulcers as assessed by upper GI endoscopy Measures of effect 1) Pooled healing rate (%) 2) Pooled Odds Ratio (OR)
- Outcome Measure
- Additional Outcome
- - Treatment-emergent adverse events
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Anti-Inflammatory Agents, Non-Steroidal; Helicobacter Infections; Helicobacter pylori; Humans; Potassium; Stomach Ulcer
- Contact
- Shupeng Zou [email protected]
- Organisational Affiliation
- Huazhong University of Science and Technology
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-10-23
- Registration Date
- 2022-11-02
- Anticipated Start Date
- 2022-10-01
- Anticipated Completion Date
- 2023-02-28
- Title Cn
- 钾离子竞争性酸阻滞剂治疗非甾体抗炎药所致胃溃疡的疗效与安全性：一项系统评价和Meta分析
- Title En
- The efficacy and safety of potassium competitive acid blocker (PCAB) in NSAID-induced gastric ulcer disease: a systematic review and meta-analysis
- Bilingual Status
- complete