Meta AnalysisID 3929
钾状态与2型糖尿病、心血管疾病及死亡风险：一项Meta分析
CRD42023366848
This meta-analysis aims to examine simultaneously the association of dietary, blood and urine potassium levels with the risk of type 2 diabetes, cardiovascular diseases (coronary heart disease and stroke) and mortality.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3929
- Evidence Id
- 12487
- Core Evidence Id
- 12487
- Source Meta Analysis Id
- 3888
- Herb2 Meta Analysis Id
- HBMA003888
- Crd Id
- CRD42023366848
- Title
- Potassium status and the risk of type 2 diabetes, cardiovascular disease and mortality：a meta-analysis
- Review Question
- This meta-analysis aims to examine simultaneously the association of dietary, blood and urine potassium levels with the risk of type 2 diabetes, cardiovascular diseases (coronary heart disease and stroke) and mortality.
- Study Type Included
- Prospective studies (cohort, case-cohort and nest case-control studies) will be included
- Condition Being Studied
- Potassium is considered as an essential mineral to be of importance for cardiometabolic health through modulating various physiological processes. Emerging evidence from experimental studies and clinical trials suggested the potential health benefits of potassium on alleviating lipid peroxides and inflammation and inhibiting platelet aggregation and thrombogenesis. Although the dietary guideline provided by the World Health Organization recommended a daily potassium intake at least 3500 mg/day for adults to decrease the risk of major chronic non-communicable diseases, actual average intake among people around the world remains far from the recommendation. Ingested potassium from foods is rapidly absorbed throughout the gastrointestinal tract and then transported actively to the bloodstream before being excreted in the urine, facilitating the maintenance of potassium homeostatic conditions. Therefore, adequate dietary potassium intake has important implications for the primary prevention of these diseases and mortality.
- Participant
- The general population aged ≥ 18 years old will be included.
- Animal
- Human Disease Modelled
- Intervention
- The highest category for potassium exposure from diet or urine; the lower and/or higher potassium level for blood potassium.
- Comparator Control
- The lowest category of potassium exposure from diet or urine and normal range of potassium level for blood potassium.
- Main Outcome
- Type 2 diabetes, cardiovascular diseases, all-cause and cardiovascular mortality Measures of effect Relative risks
- Outcome Measure
- Additional Outcome
- Coronary heart disease and stroke Measures of effect Relative risks
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus, Type 2; Diet; Humans; Potassium; Stroke
- Contact
- Yahui Fan [email protected]
- Organisational Affiliation
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
- Funding Source
- National Natural Science Foundation of China (NSFC-82022062; NSFC-81973025)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-03
- Registration Date
- 2023-01-14
- Anticipated Start Date
- 2022-09-22
- Anticipated Completion Date
- 2023-02-03
- Title Cn
- 钾状态与2型糖尿病、心血管疾病及死亡风险：一项Meta分析
- Title En
- Potassium status and the risk of type 2 diabetes, cardiovascular disease and mortality：a meta-analysis
- Bilingual Status
- complete