Meta AnalysisID 3890
黄芪多糖对环磷酰胺诱导的免疫抑制小鼠模型免疫功能的影响：Meta分析与系统评价
CRD42022337615
Can Astragalus polysaccharide enhance the immune function of cyclophosphamide-induced immunosuppressed mouse models compared with the negative controls? Population (P): cyclophosphamide-induced immunosuppressed mouse mod
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3890
- Evidence Id
- 12448
- Core Evidence Id
- 12448
- Source Meta Analysis Id
- 3847
- Herb2 Meta Analysis Id
- HBMA003847
- Crd Id
- CRD42022337615
- Title
- The Effect of Astragalus polysaccharide on immune function in cyclophosphamide-induced immunosuppressed mouse models: A Meta-Analysis and Systematic Review
- Review Question
- Can Astragalus polysaccharide enhance the immune function of cyclophosphamide-induced immunosuppressed mouse models compared with the negative controls? Population (P): cyclophosphamide-induced immunosuppressed mouse models Intervention (I): Astragalus polysaccharide Comparison (C): negative controls Outcomes (O): immune function Context and rationale Cyclophosphamide is one of the most commonly used chemotherapeutic drugs in the treatment of cancer, which can prevent the proliferation of cancer cells. However, immunosuppression as the main side effect of CTX, has caused great distress to patients. As an ancient Chinese herbal medicine, Astragalus can improve the immunity of the human body, and it is often used together with other traditional Chinese medicines to treat the immunosuppression caused by cyclophosphamide. As one of the main components of Astragalus, can Astragalus polysaccharide be used independently to improve immunity, and how effective it is, will be the issues we need to explore.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group. Exclusion criteria: Case studies; Crossover studies; Studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Mice only, regardless of gender, age, and weight, but must be injected with cyclophosphamide. Exclusion criteria: Other Drug-Induced Immunosuppression mice; mice that were also transplanted with tumors; ex vivo, in vitro and in silico models; people, rats or other animals.
- Human Disease Modelled
- Immunosuppression after chemotherapy
- Intervention
- Inclusion criteria: All durations, methods of administration and doses of astragalus polysaccharides are eligible for inclusion Exclusion criteria: Simultaneous application of astragalus polysaccharide and other drugs.
- Comparator Control
- Inclusion criteria: The control group must be induced with the same amount of cyclophosphamide as the intervention group, and can only be given saline or distilled water. Exclusion criteria: Other Chinese herbal medicines or positive medicines.
- Main Outcome
- Outcome Measure
- Inclusion criteria: 1. Immune organ index (spleen index, thymus index); 2. Peripheral blood leukocytes; 3. T lymphocyte subsets (CD4/CD8); 4. Immunoglobulins (IgA, IgG, IgM). Exclusion criteria: No relevant outcomes reported; The outcomes are displayed in the form of pictures, and precise data cannot be extracted.
- Additional Outcome
- Study Method
- Keyword
- Animals; Astragalus Plant; Cyclophosphamide; Immunity; Mice; Polysaccharides
- Contact
- Hongtai Xiong [email protected]
- Organisational Affiliation
- Guang'anmen Hospital, China Academy of Chinese Medical Sciences https://gamhospital.ac.cn/
- Funding Source
- National Natural Science Foundation of China （82174463） Grant number(s) 82174463
- Other Selection Criteria
- Inclusion criteria: all languages, all publication dates. Exclusion criteria: none.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-06-05
- Registration Date
- 2022-06-28
- Anticipated Start Date
- 2022-06-01
- Anticipated Completion Date
- 2022-12-01
- Title Cn
- 黄芪多糖对环磷酰胺诱导的免疫抑制小鼠模型免疫功能的影响：Meta分析与系统评价
- Title En
- The Effect of Astragalus polysaccharide on immune function in cyclophosphamide-induced immunosuppressed mouse models: A Meta-Analysis and Systematic Review
- Bilingual Status
- complete