Meta AnalysisID 3889
卡介菌多糖核酸对慢性荨麻疹炎症因子水平及Th1/Th2分化的影响：Meta分析与系统评价
CRD42022332475
The aim of this meta-analysis of randomized controlled trials is to evaluate the effects of BCG polysaccharide nucleic acid on levels of inflammatory factors and Th1/Th2 differentiation in chronic urticaria, furthermore
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Record Fields
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- Meta Analysis Id
- 3889
- Evidence Id
- 12447
- Core Evidence Id
- 12447
- Source Meta Analysis Id
- 3846
- Herb2 Meta Analysis Id
- HBMA003846
- Crd Id
- CRD42022332475
- Title
- Effects of BCG polysaccharide nucleic acid on levels of inflammatory factors and Th1/Th2 differentiation in chronic urticaria: Meta-analysis and a systematic review
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the effects of BCG polysaccharide nucleic acid on levels of inflammatory factors and Th1/Th2 differentiation in chronic urticaria, furthermore to evaluate the safety and effectiveness of the BCG polysaccharide nucleic acid in chronic urticaria.
- Study Type Included
- The study will only be included in randomized controlled trials，others such as case reports, animal experiments et al. will be excluded.
- Condition Being Studied
- 1.Urticaria is a localized edema reaction caused by mast cells mediated dilation and increased permeability of small vessels in skin and mucosa. Up to 20% of people will develop acute urticaria in their lifetime, while the prevalence of chronic urticaria is about 0.05%~3%. The clinical manifestations are wind masses of different sizes and pruritus. Chronic urticaria is characterized by recurrent episodes of wind mass and pruritus and lasts for more than 6 weeks. The etiology and pathogenesis of urticaria are complex and mast cells are considered to be the key effector cells in urticaria. 2.For chronic urticaria, all guidelines recommend the use of a single conventional dose of second generation H1 Antihistamines (sgAH) as first-line therapy. The sgAH antagonize only the histamine produced by mast cells, while antihistamines do not regulate the immune system of patients, so they can just only control a part of the symptoms and do not reduce the recurrence rate.Bacillus Calmette-Guerin polysaccharide nucleic acid (BCG-PSN) as immune modulators, can effectively regulate the body's immune function, correcting the imbalance of Th1/Th2 ratio. Maintain the balance and stability of cell subsets, control the release of histamine inflammatory substances, to achieve the effect of anti-allergy.
- Participant
- The study will consider participants given the diagnosis of chronic urticaria defined by clear diagnostic criteria such as The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria, Guidelines for the diagnosis and treatment of urticaria et al., irrespective of their gender, severity, education, and disease duration.
- Animal
- Human Disease Modelled
- Intervention
- The intervention drugs and methods should be limited to use BCG polysaccharide nucleic acid, and combination with sgAH (the combination drugs must be the same as the control group), the original literature requires a clear description of the dosage and course of treatment.
- Comparator Control
- The control measure should be defined as second generation H1 Antihistamines (sgAH), such as cetirizine, levositirizine, loratadine, desloratadine, fexofenadine, avastine, ibastine, epistin, midazolastine, bensulbetastine, olotadine, etc. With clear reporting of the method of medication, dosage and course of treatment.
- Main Outcome
- The main outcome measures including the Th1/Th2 cell levels and proportion (CD3, CD4, CD8, CD3/CD8), inflammatory factors levels (IL2, IL4, IL10, INF-γ, TNF-α) ,
- Outcome Measure
- Additional Outcome
- The additional outcomes including Histamine levels, IgE levels, clinical effective rate, the recurrence rate and adverse events.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- BCG Vaccine; Chronic Urticaria; Humans; Nucleic Acids; Polysaccharides; Th2 Cells
- Contact
- Qiang Fu [email protected]
- Organisational Affiliation
- ChongQing Medical University
- Funding Source
- This study was supported by no funding sources
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-13
- Registration Date
- 2022-05-24
- Anticipated Start Date
- 2022-05-01
- Anticipated Completion Date
- 2022-06-15
- Title Cn
- 卡介菌多糖核酸对慢性荨麻疹炎症因子水平及Th1/Th2分化的影响：Meta分析与系统评价
- Title En
- Effects of BCG polysaccharide nucleic acid on levels of inflammatory factors and Th1/Th2 differentiation in chronic urticaria: Meta-analysis and a systematic review
- Bilingual Status
- complete