Meta AnalysisID 3888
仙人掌多糖在糖尿病动物模型中的保护作用及其可能机制：系统评价与Meta分析
CRD42022328009
What is the effect of opuntia polysaccharides on biochemical indicators of diabetic animal models? Can opuntia polysaccharides effectively reduce blood sugar in diabetic animal models compared with the model group? Can o
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Record Fields
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- Meta Analysis Id
- 3888
- Evidence Id
- 12446
- Core Evidence Id
- 12446
- Source Meta Analysis Id
- 3845
- Herb2 Meta Analysis Id
- HBMA003845
- Crd Id
- CRD42022328009
- Title
- Protective effects and possible mechanisms of opuntia polysaccharides in an animal model of diabetes: a systematic review and meta-analysis
- Review Question
- What is the effect of opuntia polysaccharides on biochemical indicators of diabetic animal models? Can opuntia polysaccharides effectively reduce blood sugar in diabetic animal models compared with the model group? Can opuntia polysaccharides improve the high diet, high water intake and low body weight in diabetic animal models compared with the model group? Difference between opuntia polysaccharide and positive control group？ Context and rationale Diabetes is often accompanied by obesity, metabolic syndrome, or other diseases or symptoms. Blood sugar is the only criterion for clinical diagnosis of diabetes. Severe hyperglycemia will manifest the typical symptoms of high diet, high water intake, and low body weight. When blood sugar is poorly controlled, it is manifested as elevated triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. Reduced HDL cholesterol levels. Many studies have shown that the young stems of prickly pear cactus have the effect of treating diabetes and obesity. At present, they have been developed into tablets and capsules for the treatment of diabetes. As early as 1925, Shellshears et al. Lowering blood sugar concentration, cactus polysaccharide is one of the main active components isolated from cactus, although the related molecular mechanism is still unclear. To assess the available evidence for the mechanism of cactus polysaccharides in the treatment of diabetes, we will conduct a preclinical systematic review and meta-analysis.
- Study Type Included
- Inclusion criteria: Controlled studies with separate control groups Exclusion criteria: case studies; crossover studies; studies without separate control groups
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All animal models of diabetes Exclusion criteria: Human studies, cell experiments or other in vitro studies, disease models other than diabetic mellitus
- Human Disease Modelled
- Diabetes mellitus
- Intervention
- Inclusion criteria: All diabetic animals received opuntia polysaccharide treatment. There are no restrictions on the type, dose, timing and frequency of interventions Exclusion criteria: opuntia polysaccharides alone as an intervention should exclude non-cactus polysaccharides or cactus polysaccharides in combination with other drugs as an intervention
- Comparator Control
- Inclusion criteria: Unrestricted control intervention (eg, equal volume of normal saline or distilled water or no treatment) Exclusion criteria: Unrestricted intervention in the control group
- Main Outcome
- Outcome Measure
- Inclusion criteria: The main ending indicators are: diet, drinking water, weight, blood glucose (BG), secondary ending indicators; kidney weight, heart weight, blood urea nitrogen（BUN), serum creatinine (SCR), 24-hour urine protein (24-hour UP), C. MDA, plasma HBALC (%), HOMA-IR, insulin resistance indexplasma insulin, total cholesterol (TC), triglyceride (TG), Exclusion criteria: None of the primary outcome measures were described
- Additional Outcome
- Study Method
- Keyword
- Animals; Cactaceae; Diabetes Mellitus; Models, Animal; Polysaccharides
- Contact
- chen ruhai [email protected]
- Organisational Affiliation
- Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University
- Funding Source
- High level innovative talents training project of Guizhou Province (20154033) Guizhou Normal University Academic New Seedling Cultivation and Innovation Exploration Special Project ([2018]5769-27).
- Other Selection Criteria
- Inclusion criteria; written in Chinese and English. The publication period is from inception to March 2022. Exclusion criteria: in vitro studies, case reports, reviews, clinical trials, abstracts, editorials
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review, Experimental animal exposure review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-27
- Registration Date
- 2022-05-24
- Anticipated Start Date
- 2022-02-03
- Anticipated Completion Date
- 2022-09-01
- Title Cn
- 仙人掌多糖在糖尿病动物模型中的保护作用及其可能机制：系统评价与Meta分析
- Title En
- Protective effects and possible mechanisms of opuntia polysaccharides in an animal model of diabetes: a systematic review and meta-analysis
- Bilingual Status
- complete