Meta AnalysisID 3885
具有抗乳腺癌活性的多糖：系统评价与叙述性综述
CRD42020169103
Does polysaccharides treatment has antitumor effect on non clinical breast cancer models? Context and rationale Breast cancer has still remained the most incidence cancer in women worldwide despite of developments in dia
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Record Fields
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- Meta Analysis Id
- 3885
- Evidence Id
- 12443
- Core Evidence Id
- 12443
- Source Meta Analysis Id
- 3842
- Herb2 Meta Analysis Id
- HBMA003842
- Crd Id
- CRD42020169103
- Title
- Polysaccharides with antitumor effect on breast cancer: a systematic and narrative review
- Review Question
- Does polysaccharides treatment has antitumor effect on non clinical breast cancer models? Context and rationale Breast cancer has still remained the most incidence cancer in women worldwide despite of developments in diagnosis tools, prevention and treatment. Efforts is continuous given to find new treatment options with more efficacy and less adverse effects. In this context, increasing evidence highlights the important role of natural compounds, including polysaccharides, due to their biological properties in humans. Polysaccharides are widely used as biological agents for several types of diseases, such as cancer. However, a comprehensive mechanisms and related structure-activity of polysaccharides with antitumor effects on breast cancer have not been well established. Due to the importance of information from non-clinical studies (including validation of the use of these compounds and better understanding of the mechanisms by which polysaccharides promote benefit in the treatment of cancer), this systematic review will address non-clinical studies that used polysaccharides for the treatment of breast cancer. The studies should describe the structure of the polysaccharide, so that we can correlate a hypothesis about the structure-activity. Furthermore, the studies should also address in vivo (i.e.: murine female models that mimic the breast tumor) and in vitro methodologies (i.e.: that used breast cancer cell line), with appropriate comparative control group. Finally, this review will be the first to summarize all polysaccharides with antitumor effect on breast cancer and could provide information for further studies of new agents for breast cancer.
- Study Type Included
- Inclusion criteria: experimental non-clinical studies. Exclusion criteria: Case studies, cross-over studies, controlled trial, cohort studies.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: all murine models (mice or rats) with experimental breast cancer with or without metastasis, all in vitro models using breast cancer cell lines (e.g. MCF-7, MDA-MB-231, MDA-MB-468, 4T1, etc), ex vivo samples (e.g. blood, tumor tissue) of breast tumor models (human or murine). Exclusion criteria: animals with co-morbidities; male animals; animals other than mice or rats; in silico models; other cells lineages than breast cancer; ex vivo samples not from patients or animals with breast cancer.
- Human Disease Modelled
- Breast cancer in women
- Intervention
- Inclusion criteria: Evaluation of antitumor effect in vivo by polysaccharides will be trough i.e. tumor volume, tumor weigh and other analysis on tumor tissue after animal euthanasia that can raise hypotheses about the mechanism of action of the polysaccharide. All timings, frequencies and route of administration of polysaccharide treatment are eligible for inclusion. Doses below 3000 mg/kg for murine models will be included. For in vitro model’s concentrations below 3000 mg/ml and any test that evaluate antitumor effect and mechanism of action will be selected. Only treatment or incubation with isolated and extract of polysaccharides will be considered. Exclusion criteria: Exclusion criteria: For in vivo model’s dose design without pharmacological logic (i.e. dose scalation closer, doses above 3000 mg/kg); for in vitro model’s concentrations above 3000 mg/ml due to the potential toxicity in higher doses/concentrations. Studies with any other compound bound to the polysaccharides (e.g. peptides, antibody, nanoparticles) will not be selected.
- Comparator Control
- Inclusion criteria: appropriate control: vehicle-treated control animals. Exclusion criteria: Sham group, placebo group, or not vehicle-treated animals.
- Main Outcome
- Outcome Measure
- Inclusion criteria: in vivo: tumor weight, tumor volume, biochemical and molecular assays in tumor tissue to determine the effects or mechanism of action of polysaccharides. In vitro: cell viability, proliferation, migration, biochemical and molecular assays. Exclusion criteria: no relevant outcomes reported (e.g. only report cell viability without additional tests).
- Additional Outcome
- Study Method
- Keyword
- Animals; Breast Neoplasms; Polysaccharides; Rare Diseases
- Contact
- Claudia Rita Corso [email protected]
- Organisational Affiliation
- Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe Programa de Pós-graduação em Biotecnologia Aplicada à Saúde da Criança e do Adolescente Faculdades Pequeno Príncipe http://www.pelepequenoprincipe.org.br/
- Funding Source
- Other Selection Criteria
- Inclusion criteria: original articles above 2010 in English language in journals with impact factor Exclusion criteria: articles in journals without impact factor, review article, clinical trials, conferences, book chapter, book, articles below 2010 or not in English language
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-12
- Registration Date
- 2020-04-07
- Anticipated Start Date
- 2020-05-01
- Anticipated Completion Date
- 2020-07-01
- Title Cn
- 具有抗乳腺癌活性的多糖：系统评价与叙述性综述
- Title En
- Polysaccharides with antitumor effect on breast cancer: a systematic and narrative review
- Bilingual Status
- complete