Meta AnalysisID 3881
古巴多廿烷醇治疗高脂血症的临床有效性与安全性：一项Meta分析与系统评价
CRD42020147456
This study aimed to systematically investigate whether Cuban Policosanol was effective and safe on dyslipidemia.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3881
- Evidence Id
- 12439
- Core Evidence Id
- 12439
- Source Meta Analysis Id
- 3838
- Herb2 Meta Analysis Id
- HBMA003838
- Crd Id
- CRD42020147456
- Title
- Clinical efficacy and safety of Cuban policosanol for the treatment of hyperlipidemia: a meta-analysis and systematic review
- Review Question
- This study aimed to systematically investigate whether Cuban Policosanol was effective and safe on dyslipidemia.
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Dyslipidemia is a major risk factor for cardiovascular and cerebrovascular diseases. It could induce atherosclerosis, leading to coronary heart disease, stroke, and myocardial infarction, increasing the incidence and mortality rate of cardio-cerebrovascular diseases.
- Participant
- Participants, adult patients (18 years of age and older) with dyslipidemia.
- Animal
- Human Disease Modelled
- Intervention
- The therapy used Cuban Policosanol.
- Comparator Control
- Control group: placebo, blank control, and conventional western medicine (such as stains).
- Main Outcome
- The primary outcome indicators are determined according to the Guiding Principles for Clinical Research of Drugs: markedly effective: TC decreased ≥20% or TG decreased ≥40% or HDL-C increased ≥0.26 mmol/L; effective: TC decreased by 10% to 20% or TG decreased by 20% to 40% or HDL-C increased by 0.10 to 0.26 mmol/L; invalid: did not meet the above criteria. Measures of effect The administration time for both the control and experimental groups must not be less than 4 weeks.
- Outcome Measure
- Additional Outcome
- The secondary outcome includes Serum TC, TG, LDL-C, HDL-C, apolipoprotein A (apo A), apo B Measures of effect The administration time for both the control and experimental groups must not be less than 4 weeks.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Fatty Alcohols; Humans; Hyperlipidemias; Treatment Outcome; policosanol
- Contact
- Chuan Wang [email protected]
- Organisational Affiliation
- Shaanxi University of Chinese Medicine
- Funding Source
- This research was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81800401) and Subject Innovation Team of Shaanxi University of Chinese Medicine (2019-YL13)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-08-15
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-09-01
- Anticipated Completion Date
- 2020-12-01
- Title Cn
- 古巴多廿烷醇治疗高脂血症的临床有效性与安全性：一项Meta分析与系统评价
- Title En
- Clinical efficacy and safety of Cuban policosanol for the treatment of hyperlipidemia: a meta-analysis and systematic review
- Bilingual Status
- complete