Meta AnalysisID 3875
氟化钠诱导的神经行为损害的研究前景：临床前证据的系统评价
CRD42022346532
Whether sodium fluoride can cause neurobehavioral impairment in experimental animals (Mice and Rats) in comparison to untreated group? Context and rationale Sodium fluoride is one of the major environmental toxicants and
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3875
- Evidence Id
- 12433
- Core Evidence Id
- 12433
- Source Meta Analysis Id
- 3832
- Herb2 Meta Analysis Id
- HBMA003832
- Crd Id
- CRD42022346532
- Title
- Perspectives of sodium fluoride induced neurobehavioral impairments - A systematic review of preclinical evidences
- Review Question
- Whether sodium fluoride can cause neurobehavioral impairment in experimental animals (Mice and Rats) in comparison to untreated group? Context and rationale Sodium fluoride is one of the major environmental toxicants and is often present at higher concentrations in the drinking water. More than 25 countries around the world have discovered evidence connecting sodium fluoride to health issues. According to WHO estimates from 1984, more than 260 million people consume water with more than 1 mg/L of sodium fluoride. Sodium fluoride can cross the blood brain barrier and can lead to generation of free radicals, increase in lipid peroxidation, depletion of anti-oxidants and restriction of protein synthesis. Studies have shown that sodium fluoride causes neuroinflammation and apoptosis which play a pivotal role in the progression of various neurodegenerative diseases. Chronic exposure of Sodium fluoride can cause neuronal damage along with histological, behavioral and cognitive effects in experimental animals and humans. The main aim of this review is to elicit the influence of sodium fluoride on neurobehavioral impairments in experimental animals and warrant a thorough investigation of the existing literature.
- Study Type Included
- Inclusion criteria: Study designs involving only NaF exposure and control group will be included in our review Exclusion criteria: case studies, case control studies, randomized control studies, or any kind of clinical study will be exempted from the review
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Rat and mice induction models of all genders and age, Transgenic mice and Transgenic rat models. Exclusion criteria: Insilico studies, Studies on Cell lines, Studies done on animals other than rats/mice, Clinical studies, Interventional studies.
- Human Disease Modelled
- Neurobehavioral impairment
- Intervention
- Inclusion criteria: Exposure duration of sodium fluoride: Till 300 days Dose of Sodium fluoride: 300 ppm (or) 300 mg/L Mode of exposure: Drinking water/ Parenteral or Oral route Exclusion criteria: Any other toxicants or pollutants other than Sodium fluoride, combination of Sodium fluoride with any other toxicants or pollutants and Interventional studies like drug/molecule/Plant extract effect against sodium fluoride toxicity.
- Comparator Control
- Inclusion criteria: Control (Sodium fluoride free/untreated) Exclusion criteria: Groups having comorbidities
- Main Outcome
- Outcome Measure
- Inclusion criteria: Acetylcholinesterase, Butyryl cholinesterase, neuroprotective markers, antioxidant levels, oxidative markers, apoptotic markers, histopathology of brain, any other neurodegenerative markers, neuroinflammatory markers, behavioral interventions, RT-PCR, western blot analysis, gene expression studies, HPLC analysis of amyloid beta and tau protein, Redox assay, immunofluorescence assay, TUNEL assay, mitochondrial assay. Exclusion criteria: Various Outcomes which are of no interest in developing neurobehavioral impairments will be exempted from review
- Additional Outcome
- Study Method
- Keyword
- Animals; Antioxidants; Apoptosis; Blood-Brain Barrier; Cognition; Drinking Water; Free Radicals; Humans; Lipid Peroxidation; Mice; Neurodegenerative Diseases; Neuroinflammatory Diseases; Rats; Sodium Fluoride; World Health Organization
- Contact
- Arunkumar Subramanian [email protected]
- Organisational Affiliation
- SRM College of Pharmacy, SRM Institute of Science and Technology <b>https://www.srmist.edu.in/medicine/college-pharmacy/about-the-department</b>
- Funding Source
- No Funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-29
- Registration Date
- 2022-11-08
- Anticipated Start Date
- 2022-08-15
- Anticipated Completion Date
- 2023-02-15
- Title Cn
- 氟化钠诱导的神经行为损害的研究前景：临床前证据的系统评价
- Title En
- Perspectives of sodium fluoride induced neurobehavioral impairments - A systematic review of preclinical evidences
- Bilingual Status
- complete