Meta AnalysisID 3873
毛果芸香碱、西维美林和地夸磷索与人工泪液比较治疗干眼的安全性与有效性：系统评价与Meta分析
CRD42020218407
Patients: Patients with dry eyes. Intervention: Use of Secretagogues. Comparison: Artificial tears without preservatives. Outcome: Ocular surface disease index.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3873
- Evidence Id
- 12431
- Core Evidence Id
- 12431
- Source Meta Analysis Id
- 3829
- Herb2 Meta Analysis Id
- HBMA003829
- Crd Id
- CRD42020218407
- Title
- Safety and Efficacy of Pilocarpine, Cevimeline and Diquafosol compared to Artificial Tears for the treatment of dry eye: Systematic Review and Meta-analysis.
- Review Question
- Patients: Patients with dry eyes. Intervention: Use of Secretagogues. Comparison: Artificial tears without preservatives. Outcome: Ocular surface disease index.
- Study Type Included
- We will include randomized controlled trials that compare secretagogues and artificial tears.
- Condition Being Studied
- Dry eye disease (DED) is a condition that affects the ocular surface and affects millions of people around the world. In recent years a stepped scheme has been proposed for the treatment of DED, with the use of an artificial tear being the mainstay of treatment. In this scheme, the use of secretagogues is suggested as part of the treatment for patients with moderate to severe affectation. With this systematic review we aim to evaluate the effectiveness and safety of secretagogues for DED.
- Participant
- We will include trials where the study population comprises people 18 years old or older with dry eye disease.
- Animal
- Human Disease Modelled
- Intervention
- Secretagogues, including Pilocarpine, Cevimeline and Diquafosol
- Comparator Control
- Artificial Tears intervention with different types.
- Main Outcome
- • Tear film breakdown time • Ocular Surface Disease Index score • Schirmer test score Measures of effect We will calculate mean difference (MDs) with 95% confidence intervals (CIs) for continuous measures and risk ratios (RRs) with the corresponding 95% CIs for dichotomous outcomes to estimate effects. We will choose a cut-off for ordinal outcomes and measurement scales to handle them as binary data or treat them as continuous data, as appropriate.
- Outcome Measure
- Additional Outcome
- • Vision-Related Quality of Life (VRQoL) questionnaire • Osmolarity • Adverse events • Fluorescein staining score Measures of effect We will calculate mean difference (MDs) with 95% confidence intervals (CIs) for continuous measures and risk ratios (RRs) with the corresponding 95% CIs for dichotomous outcomes to estimate effects. We will choose a cut-off for ordinal outcomes and measurement scales to handle them as binary data or treat them as continuous data, as appropriate.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Dry Eye Syndromes; Humans; Lubricant Eye Drops; Pilocarpine; cevimeline; diquafosol
- Contact
- Nicolás Kahuam-López [email protected]
- Organisational Affiliation
- Centro de Investigacion en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud, Universidad Anahuac México, Campus Norte, Huixquilucan, Mexico. Cornea and Refractive Surgery Department, Instituto de Oſtalmologia Fundación Conde de Valenciana, Mexico City, Mexico. https://www.anahuac.mx/mexico/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Mexico
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-07
- Registration Date
- 2020-12-08
- Anticipated Start Date
- 2021-02-01
- Anticipated Completion Date
- 2022-02-01
- Title Cn
- 毛果芸香碱、西维美林和地夸磷索与人工泪液比较治疗干眼的安全性与有效性：系统评价与Meta分析
- Title En
- Safety and Efficacy of Pilocarpine, Cevimeline and Diquafosol compared to Artificial Tears for the treatment of dry eye: Systematic Review and Meta-analysis.
- Bilingual Status
- complete