Meta AnalysisID 3868
毒扁豆碱对急诊抗毒蕈碱中毒成人气管插管需求及ICU入住的影响：系统评价与Meta分析
CRD42022308519
1) How does physostigmine administration in patients presenting in an emergency medical setting with antimuscarinic toxicity affect the proportion requiring intubation? 2) How does physostigmine administration in patien
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3868
- Evidence Id
- 12426
- Core Evidence Id
- 12426
- Source Meta Analysis Id
- 3823
- Herb2 Meta Analysis Id
- HBMA003823
- Crd Id
- CRD42022308519
- Title
- The effects of physostigmine on need for intubation and ICU admission in adults presenting emergently with antimuscarinic toxicity: A systematic review and meta-analysis
- Review Question
- 1) How does physostigmine administration in patients presenting in an emergency medical setting with antimuscarinic toxicity affect the proportion requiring intubation? 2) How does physostigmine administration in patients presenting in an emergency medical setting with antimuscarinic toxicity affect the proportion requiring ICU admission?
- Study Type Included
- Randomised controlled trials, cohort studies including retrospective and prospective studies will be considered. Lower levels of evidence such as case series and singular case studies will be excluded.
- Condition Being Studied
- Antimuscarinic toxicity presents when a patient has an excess of an antimuscarinic substance introduced into their system. It may present with confusion, agitation, hallucinations, and carphologia, as well as dry mucous membranes, tachycardia, and mydriasis. This is commonly treated using supportive measures only, and may lead to higher than necessary rates of tracheal intubation and critical care.
- Participant
- Inclusion criteria: - Adults (patients aged 18 years or older) - Prehospital or emergency department setting - Antimuscarinic toxicity, or suspected antimuscarinic toxicity Exclusion criteria: - Peri-operative patients
- Animal
- Human Disease Modelled
- Intervention
- Any use of physostigmine, in an emergency setting, for known or suspected antimuscarinic toxicity.
- Comparator Control
- Standard supportive care. This extends to the use of sedatives, anti-epileptic drugs, and electrolyte solutions.
- Main Outcome
- 1) Whether a patient was intubated or not 2) Whether a patient was admitted to ICU or not These dichotomous outcomes will be measured as per below. Measures of effect Results will be extracted as total numbers of patients, number of patients with the outcome, subsequent percentages, and odds ratios (where calculated).
- Outcome Measure
- Additional Outcome
- Delirium control and use of CT imaging will also be investigated. Measures of effect Results will be extracted as total numbers of patients, number of patients with the outcome, subsequent percentages, and odds ratios (where calculated).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Adult; Cholinesterase Inhibitors; Humans; Intensive Care Units; Intubation, Intratracheal; Muscarinic Antagonists; Physostigmine
- Contact
- Youri Wijland [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- New Zealand
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-02-21
- Registration Date
- 2022-03-24
- Anticipated Start Date
- 2022-02-23
- Anticipated Completion Date
- 2022-12-30
- Title Cn
- 毒扁豆碱对急诊抗毒蕈碱中毒成人气管插管需求及ICU入住的影响：系统评价与Meta分析
- Title En
- The effects of physostigmine on need for intubation and ICU admission in adults presenting emergently with antimuscarinic toxicity: A systematic review and meta-analysis
- Bilingual Status
- complete