Meta AnalysisID 3867
节旋藻（同义名：螺旋藻）和C-藻蓝蛋白作为肾保护营养补充剂对肾脏疾病的作用：系统评价与Meta分析
CRD42022358264
The cyanobacterium Spirulina sp. which is already well known as a protein source for human and animal food, can it contribute as a nutraceutical food in the diet of patients with kidney problems, especially those with ch
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Record Fields
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- Meta Analysis Id
- 3867
- Evidence Id
- 12425
- Core Evidence Id
- 12425
- Source Meta Analysis Id
- 3822
- Herb2 Meta Analysis Id
- HBMA003822
- Crd Id
- CRD42022358264
- Title
- Arthrospira sp. (sin. Spirulina sp.) and C-phycocyanin as nephroprotective nutraceutical supplement on kidney diseases: a systematic review and meta-analysis
- Review Question
- The cyanobacterium Spirulina sp. which is already well known as a protein source for human and animal food, can it contribute as a nutraceutical food in the diet of patients with kidney problems, especially those with chronic kidney disease and hypertension? Context and rationale Arthrospira (sin. Spirulina) is a blue-green cyanobacterium considered by the ONU as a superfood of the future. The photosynthetic pigment phycocyanin (included in the group of phycobiliproteins) present in Spirulina, has been associated as a potential source of bioactives with nephroprotective properties. Arterial hypertension (AH) is a multifactorial condition associated with genetic and epigenetic factors, cardio and renal metabolic (e.g., dyslipidemia, abdominal obesity, glucose intolerance, and diabetes mellitus), environmental and social factors and is classified as one of the chronic noncommunicable diseases (NCDs). In 2019, Global Burden of Cardiovascular Diseases and Risk Factors reported that approximately 828 million adults with AH were reported worldwide and is related to the development of cardiovascular diseases (CVD), chronic kidney disease (CKD), stroke and early mortality. There are a considerable number of preclinical studies using Spirulina in the treatment of hypertension. Clinical studies evaluating the nutraceutical potential of cyanobacterial and microalgae species, especially Arthrospira sp. are currently scarce focusing on the secondary cause of hypertension. In this context, this work evaluates the effect of consuming Arthrospira (sin. Spirulina) and C-phycocyanin on the prevention of hypertension and kidney disease.
- Study Type Included
- Inclusion criteria: Randomized preclinical studies using groups of all sexes. Exclusion criteria: Studies with designs other than randomized preclinical trials.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All animal models with experimental hypertension or/and kidney diseases; all species and all sexes. Exclusion criteria: Animals with co-morbidities; ex vivo, in vitro and in silico models.
- Human Disease Modelled
- Hypertension and kidney diseases.
- Intervention
- Inclusion criteria: Treatment using Spirulina, Arthrospira, or C-phycocyanin isolated or in combination with alternative active ingredients for the treatment of kidney disease and/or hypertension, with at least two weeks of intervention. Exclusion criteria: Intervention time less than two weeks.
- Comparator Control
- Inclusion criteria: Use of placebo group with saline solution, sham group, positive control group with drugs known in clinical practice. Exclusion criteria: All other control conditions; absence of a control or placebo group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Serum concentrations of creatinine, urea, uric acid and proteinuria. In addition to systolic and diastolic blood pressure levels. Exclusion criteria: Absence of mean and standard deviation of the results concerning the levels of SDB and DBP, serum creatinine, uric acid, urea, and total proteins.
- Additional Outcome
- Study Method
- Keyword
- Animals; Antihypertensive Agents; Cardiovascular Diseases; Diabetes Mellitus; Diet; Dietary Supplements; Dyslipidemias; Epigenesis, Genetic; Glucose Intolerance; Humans; Hypertension; Kidney; Microalgae; Noncommunicable Diseases; Obesity, Abdominal; Phycocyanin; Renal Insufficiency, Chronic; Risk Factors; Social Factors; Spirulina; Stroke
- Contact
- Raquel Pedrosa Bezerra [email protected]
- Organisational Affiliation
- Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco
- Funding Source
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) – [Finance Code 001; 88887.485013/2020-00] and by the Foundation for Science and Technology of the State of Pernambuco [FACEPE, APQ-0252-5.07/14].
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-09-07
- Registration Date
- 2022-09-30
- Anticipated Start Date
- 2022-05-02
- Anticipated Completion Date
- 2022-11-30
- Title Cn
- 节旋藻（同义名：螺旋藻）和C-藻蓝蛋白作为肾保护营养补充剂对肾脏疾病的作用：系统评价与Meta分析
- Title En
- Arthrospira sp. (sin. Spirulina sp.) and C-phycocyanin as nephroprotective nutraceutical supplement on kidney diseases: a systematic review and meta-analysis
- Bilingual Status
- complete