Meta AnalysisID 3864
产前及幼儿期邻苯二甲酸酯暴露对湿疹的影响：系统评价与Meta分析
CRD42022319354
The aim of this meta-analysis is to evaluate the relationship between phthalate exposure and risk of eczema in children.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3864
- Evidence Id
- 12422
- Core Evidence Id
- 12422
- Source Meta Analysis Id
- 3819
- Herb2 Meta Analysis Id
- HBMA003819
- Crd Id
- CRD42022319354
- Title
- Impact of prenatal and early childhood exposure to phthalate on eczema: a systematic review and meta-analysis
- Review Question
- The aim of this meta-analysis is to evaluate the relationship between phthalate exposure and risk of eczema in children.
- Study Type Included
- The study was an observational study design, including a cohort study, cross-sectional study, or case-control study.
- Condition Being Studied
- Eczema is a common chronic inflammatory skin disorder characterized by dry skin and itching and is a global public health concern. In recent years, the prevalence of eczema especially in children has increased rapidly, which has caused a considerable personal and public health burden. Therefore, it’s particularly necessary to identify modifiable risk factors for the prevention of eczema. Studies suggest that eczema has a complex etiology including genetic factors and immune system disorder. In addition, there is accumulating evidence indicating that environmental chemical exposure involves in the development of eczema.
- Participant
- The study must contain case group of eczema and control group without eczema; Participants with eczema (as diagnosed by a clinician, questionnaire according to the International Study of Asthma and Allergies in Childhood questionnaire, or using any recognized diagnostic criteria) will be included. And the study was conducted in animals or was molecular experiment will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The study that measured levels of phthalates or phthalate metabolites in the samples including biological samples (maternal urine, serum, and cord blood, children's urine), and environmental dust sample
- Comparator Control
- Effects of higher levels of phthalate or metabolites vs. that of lower levels on eczema risk were compared, presented as odds ratio (OR), relative risk (RR) or hazard ratio (HR) with 95% confident interval (CI), or had extractable data to calculate the risk estimate;
- Main Outcome
- Eczema that is diagnosed by a clinician, questionnaire according to the International Study of Asthma and Allergies in Childhood questionnaire, or using any recognized diagnostic criteria.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Child, Preschool; Eczema; Female; Humans; Phthalic Acids; Pregnancy; phthalic acid
- Contact
- Hong Zhang [email protected]
- Organisational Affiliation
- Fujian Normal University
- Funding Source
- the Research Start-up Fund of Fujian Normal University, China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> The grant number is Y0720304X13.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-22
- Registration Date
- 2022-04-22
- Anticipated Start Date
- 2022-03-19
- Anticipated Completion Date
- 2022-06-19
- Title Cn
- 产前及幼儿期邻苯二甲酸酯暴露对湿疹的影响：系统评价与Meta分析
- Title En
- Impact of prenatal and early childhood exposure to phthalate on eczema: a systematic review and meta-analysis
- Bilingual Status
- complete