Meta AnalysisID 3862
邻苯二甲酸酯暴露与糖尿病风险：系统评价与Meta分析的启示
CRD42021273777
(1) Is phthalate exposure associated with elevated risk of diabetes in humans? (2) If the answer of question one is positive, then which kind of phthalate correlates with diabetes? (3) Is phthalate exposure associated wi
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3862
- Evidence Id
- 12420
- Core Evidence Id
- 12420
- Source Meta Analysis Id
- 3817
- Herb2 Meta Analysis Id
- HBMA003817
- Crd Id
- CRD42021273777
- Title
- Phthalate exposure and risk of diabetes mellitus: implications from a systematic review and meta-analysis
- Review Question
- (1) Is phthalate exposure associated with elevated risk of diabetes in humans? (2) If the answer of question one is positive, then which kind of phthalate correlates with diabetes? (3) Is phthalate exposure associated with insulin resistance in humans? If yes, which kind?
- Study Type Included
- Cohort study, case-control study, or cross-sectional study
- Condition Being Studied
- Diabetes mellitus (DM) has caused huge disease-economic burden and addressed deep public concern worldwide. It was reported that global prevalence of diabetes among adults was nearly 9.3% in the year of 2019, which indicated about 463 million adults had diabetes, and this number would increase to 700 million in 2045. Although many typical risk factors of DM have been identified, such as obesity, physical inactivity, unhealthy diet and family history of diabetes, risk factors and etiology of DM has not been fully revealed. In recent years, environmental endocrine disruptors, especially phthalate exposure, have been shown to be associated with risk of diabetes with inconsistent resutls. The potential hazardous effects of phthalate on DM and insulin resistance risk is not fully understood.
- Participant
- For studies regarding phthalate and diabetes, the study must contain case group of diabetic humans and control group without diabetes. For studies concerning phthalate and insulin resistance, the study included humans with or without diabetes.
- Animal
- Human Disease Modelled
- Intervention
- Exposure includes phthalate of its metabolites, as detected in human samples, such as blood, urine, hair, etc.
- Comparator Control
- For studies on phthalate and diabetes, the comparasion refers to effects of higher levels of phthalate or metabolites vs. that of lower levels on diabetes risk, presented as odds ratio (OR), risk ratio (RR) or hazard ratio (HR) with 95% confident interval (CI). For studies on phthalate and insulin resistance, the comparason refers to effects of higher levels of phthalate or metabolites vs. that of lower levels on insulin resistance.
- Main Outcome
- For studies on phthalate and diabetes, the outcome was defines as confirmed diabetes other than gestational diabetes diagnosed by doctors. For studies on phthalate and insulin resistance, the outcome referred to insulin resistance quantified with homeostasis model assessment (HOMA-IR) or its indices including serum fasting glucose, fasting insulin, or serum glycosylated hemoglobin. Measures of effect For studies on phthalate and diabetes, effect estimates included relative risks (RRs), odds ratios (ORs), or hazard ratios (HRs). For studies on phthalate and insulin resistance, effec estimates included ORs, RRs, HRs or correlation coefficients (sch as β-coefficient, etc.)
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Diabetes Mellitus, Type 2; Humans; Phthalic Acids; phthalic acid
- Contact
- Hong Zhang [email protected]
- Organisational Affiliation
- Fujian Normal University
- Funding Source
- The Scientific Research Project of the Education Department of Fujian Province, China Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Grant number JAT190081
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-31
- Registration Date
- 2021-09-30
- Anticipated Start Date
- 2021-01-29
- Anticipated Completion Date
- 2021-09-29
- Title Cn
- 邻苯二甲酸酯暴露与糖尿病风险：系统评价与Meta分析的启示
- Title En
- Phthalate exposure and risk of diabetes mellitus: implications from a systematic review and meta-analysis
- Bilingual Status
- complete