Meta AnalysisID 3861
邻苯二甲酸酯暴露与孤独症谱系障碍的关联：系统评价与Meta分析
CRD42021235836
Is phthalate exposure associated with autism? Is there a dose-response relationship between phthalate exposure and the onset or severity of autism? What is the effect of phthalate exposure on autism patients with subgrou
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Record Fields
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- Meta Analysis Id
- 3861
- Evidence Id
- 12419
- Core Evidence Id
- 12419
- Source Meta Analysis Id
- 3816
- Herb2 Meta Analysis Id
- HBMA003816
- Crd Id
- CRD42021235836
- Title
- The association of phthalate exposure and autism spectrum disorders: a systematic review and meta-analysis
- Review Question
- Is phthalate exposure associated with autism? Is there a dose-response relationship between phthalate exposure and the onset or severity of autism? What is the effect of phthalate exposure on autism patients with subgroups(age(e.g. children and adolescents)and the period of exposure(e.g. during pregnancy and childhood))?
- Study Type Included
- Original studies including cohort studies, case-control studies and cross-sectional studies reporting the association between phthalates exposure and autism spectrum disorders will be included. Book, Commentary, RCT, case reports, dissertation publications, reviews, editorials, letters to the editors, abstracts from conferences/meetings and interventional studies will be excluded.
- Condition Being Studied
- Phthalate esters, a kind of polyvinyl chloride plasticizer, are added to polymers to enhance the flexibility and tensile properties of materials, so they are used in many consumables, such as personal care products, medical equipment. However, phthalates are easily released from plastics, and enter the human body through the digestive tract, respiratory tract and skin through water, atmosphere and soil, so the possibility of non-occupational exposure to phthalates is very high. Autism is a group of heterogeneous neurodevelopmental conditions characterized by early-onset social disorders and abnormally limited, repetitive behaviors and interests. According to a report released by Centers for Disease Control in 2018, the total prevalence rate of Autism Spectrum Disorders(ASD) in 8-year-old children is 1.68%(Baio et al., 2018). But new surveillance data in 2020 show a slight increase (1.85%)(Maenner et al., 2020). Recently, it has been found that environmental factors are related to the pathogenesis of ASD, and there are polymorphisms in the environmental toxin detoxification genes of ASD, suggesting the interaction between genetic and environmental factors in the pathogenesis of autism. A Swedish study showed a heritability of 50%, supporting the equally powerful role of environmental risk factors(Sandin et al., 2014).
- Participant
- Patients who are diagnosed as Autism Spectrum Disorders(ASD)
- Animal
- Human Disease Modelled
- Intervention
- Phthalate exposure
- Comparator Control
- Healthy population
- Main Outcome
- The association between phthalate exposure and autism spectrum disorders. Measures of effect Timing and effect measures. Outcomes taken at baseline of case-control study, cohort study or cross-sectional study will be included.
- Outcome Measure
- Additional Outcome
- The dose-response relationship between phthalate exposure and the onset or severity of autism. Subgroups of the age, phthalate exposure, gender, region, diagnostic criteria for autism take effect in the association between phthalate exposure and autism. Measures of effect Timing and effect measures. Outcomes taken at baseline of case-control study, cohort study or cross-sectional study will be included.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Autism Spectrum Disorder; Humans; Phthalic Acids; phthalic acid
- Contact
- Peng Xiong [email protected]
- Organisational Affiliation
- Mental Health and Behavioral Sciences Research Group, School of Medicine, Jinan University
- Funding Source
- This study is supported by“the Fundamental Research Funds for the Central Universities”21619333.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-02-07
- Registration Date
- 2021-03-09
- Anticipated Start Date
- 2021-02-01
- Anticipated Completion Date
- 2021-05-01
- Title Cn
- 邻苯二甲酸酯暴露与孤独症谱系障碍的关联：系统评价与Meta分析
- Title En
- The association of phthalate exposure and autism spectrum disorders: a systematic review and meta-analysis
- Bilingual Status
- complete