Meta AnalysisID 3856
腰麻下剖宫产术中预防性使用去氧肾上腺素与胶体预扩容对产妇及新生儿影响的Meta分析
CRD42021272656
The aim of this meta-analysis of randomized controlled trials is to evaluate the effects of preventive use of phenylephrine and colloidal pre-dilatation on Parturients and newborns during cesarean section under spinal an
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Record Fields
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- Meta Analysis Id
- 3856
- Evidence Id
- 12414
- Core Evidence Id
- 12414
- Source Meta Analysis Id
- 3811
- Herb2 Meta Analysis Id
- HBMA003811
- Crd Id
- CRD42021272656
- Title
- A meta-analysis of the effects of preventive use of phenylephrine and colloidal pre-dilatation on Parturients and newborns during cesarean section under spinal anesthesia
- Review Question
- The aim of this meta-analysis of randomized controlled trials is to evaluate the effects of preventive use of phenylephrine and colloidal pre-dilatation on Parturients and newborns during cesarean section under spinal anesthesia
- Study Type Included
- Randomized controlled trials (RCTs) will be included
- Condition Being Studied
- Supine hypotension is the main complication of the cesarean section of the parturient. After intraspinal anesthesia, the tension of the arterioles decreases, the enlarged uterus compresses the inferior vena cava, and the relative/absolute blood volume of the parturient increases. The incidence of hypotension is low. Intraoperative hypotension can cause nausea, vomiting, dizziness, heart failure, etc., which can threaten the safety of mothers and babies in severe cases. According to relevant literature reports, preventive administration of phenylephrine and colloidal pre-dilatation are effective ways to prevent and treat maternal hypotension. Phenylephrine, as a pure α-adrenergic receptor (α-receptor) agonist, is currently recommended in the relevant domestic and foreign guidelines for the prevention and treatment of maternal hypotension after caesarean section IA. However, this The medicine causes the blood vessels of the parturient to constrict at the same time, which can induce a decrease in reflex heart rate. Colloid pre-expansion is also one of the main methods to prevent and treat hypotension in the supine position of the parturient, but it may aggravate the heart load of the parturient and cause heart failure.
- Participant
- Parturients undergoing cesarean section under spinal anesthesia will be included
- Animal
- Human Disease Modelled
- Intervention
- Preventive use of phenylephrine (intravenous injection or continuous infusion) in puerperant in the intervention group
- Comparator Control
- Colloid pre-expansion in puerperant in the comparater group
- Main Outcome
- The main outcome indicators were the incidence of maternal hypotension and the pH value in the results of neonatal umbilical artery blood gas analysis Measures of effect Choose RR/OR for binary variables and SMD/MD for continuous variables
- Outcome Measure
- Additional Outcome
- The secondary outcome indicators were the incidence of maternal hypertension, bradycardia, tachycardia, nausea and vomiting, and cardiac output. As well as the Apgar score after birth of the newborn, the partial pressure of oxygen in the arterial blood, the partial pressure of carbon dioxide, and the alkali excess in the results of the umbilical artery blood gas analysis. Measures of effect Choose RR/OR for binary variables and SMD/MD for continuous variables
- Study Method
- Intervention, Systematic review
- Keyword
- Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Dilatation; Female; Humans; Infant, Newborn; Phenylephrine; Pregnancy
- Contact
- wang xiao-bin [email protected]
- Organisational Affiliation
- Department of Anesthesiology, Affiliated Hospital of Southwest Medical University
- Funding Source
- no
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-08-09
- Registration Date
- 2021-09-10
- Anticipated Start Date
- 2021-07-19
- Anticipated Completion Date
- 2021-09-30
- Title Cn
- 腰麻下剖宫产术中预防性使用去氧肾上腺素与胶体预扩容对产妇及新生儿影响的Meta分析
- Title En
- A meta-analysis of the effects of preventive use of phenylephrine and colloidal pre-dilatation on Parturients and newborns during cesarean section under spinal anesthesia
- Bilingual Status
- complete