Meta AnalysisID 3854
去氧肾上腺素对清醒成年人类受试者脑氧合及大脑中动脉血流速度的影响：一项系统评价计划书
CRD42020207110
In awake, adult, human participants without neurological disease: (1)What is the effect of intravenous phenylephrine on cerebral oxygen saturation (COS)?, (2) What is the effect of intravenous phenylephrine on cardiac ou
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Record Fields
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- Meta Analysis Id
- 3854
- Evidence Id
- 12412
- Core Evidence Id
- 12412
- Source Meta Analysis Id
- 3809
- Herb2 Meta Analysis Id
- HBMA003809
- Crd Id
- CRD42020207110
- Title
- The effect of phenylephrine on cerebral oxygenation and middle cerebral artery blood flow velocity in awake, adult, human participants: a systematic review protocol
- Review Question
- In awake, adult, human participants without neurological disease: (1)What is the effect of intravenous phenylephrine on cerebral oxygen saturation (COS)?, (2) What is the effect of intravenous phenylephrine on cardiac output and middle cerebral artery blood flow velocity (MCAv)? Other measures of cerebral perfusion will also be considered if included in the study design.
- Study Type Included
- This systematic review will consider both experimental and quasi-experimental study designs including randomized controlled trials, non-randomized controlled trials, before and after studies and interrupted time-series studies. Only studies published in English will be considered. Studies published since 1999 will be included.
- Condition Being Studied
- Cerebral perfusion, measured via cerebral oxygen saturation and middle cerebral artery blood flow velocity
- Participant
- The systematic review will consider studies of male and female human participants 18 years or older who are awake and not undergoing general, regional or sedation anesthesia. Participants with a history of intracranial neurological disease will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The systematic review will consider studies that evaluate the effect of intravenous phenylephrine administered as a bolus or continuous infusion
- Comparator Control
- This systemic review will consider studies that compare the intervention to pre and post administration, placebo, or other vasopressors such as epinephrine, norepinephrine and dopamine.
- Main Outcome
- This systematic review will include outcomes that measure the effect of phenylephrine on cerebral oxygen saturation and middle cerebral artery (MCA) blood flow velocity. Measures of effect Papers will, where possible be pooled in statistical meta-analysis using JBI SUMARI. Effect sizes will be expressed as either odds ratios (for dichotomous data), and weighted (or standardized) mean differences (for continuous data) and their 95% confidence intervals will be calculated for analysis. Heterogeneity will be assessed statistically using the standard chisquare and I² tests.
- Outcome Measure
- Additional Outcome
- Other outcome measures of cerebral perfusion identified in selected studies will be considered. Measures of effect Papers will, where possible be pooled in statistical meta-analysis using JBI SUMARI. Effect sizes will be expressed as either odds ratios (for dichotomous data), and weighted (or standardized) mean differences (for continuous data) and their 95% confidence intervals will be calculated for analysis. Heterogeneity will be assessed statistically using the standard chisquare and I² tests.
- Study Method
- Systematic review
- Keyword
- Adult; Blood Flow Velocity; Humans; Middle Cerebral Artery; Phenylephrine; Ultrasonography, Doppler, Transcranial; Wakefulness
- Contact
- Palwasha Syar, BS, MS3 [email protected]
- Organisational Affiliation
- Rosalind Franklin University of Medicine and Science rosalindfranklin.edu
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-03
- Registration Date
- 2020-11-03
- Anticipated Start Date
- 2019-10-01
- Anticipated Completion Date
- 2021-01-04
- Title Cn
- 去氧肾上腺素对清醒成年人类受试者脑氧合及大脑中动脉血流速度的影响：一项系统评价计划书
- Title En
- The effect of phenylephrine on cerebral oxygenation and middle cerebral artery blood flow velocity in awake, adult, human participants: a systematic review protocol
- Bilingual Status
- complete