Meta AnalysisID 3850
罂粟碱与动脉瘤性蛛网膜下腔出血后结局：系统评价与Meta分析
CRD42021283057
What are the outcomes following administration of papaverine in aneurysmal subarachnoid haemorrhage? Population (P): Patients with aneurysmal subarachnoid haemorrhage Intervention (I): Papaverine; topical or intravenous
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3850
- Evidence Id
- 12408
- Core Evidence Id
- 12408
- Source Meta Analysis Id
- 3804
- Herb2 Meta Analysis Id
- HBMA003804
- Crd Id
- CRD42021283057
- Title
- Papaverine and outcome following aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis
- Review Question
- What are the outcomes following administration of papaverine in aneurysmal subarachnoid haemorrhage? Population (P): Patients with aneurysmal subarachnoid haemorrhage Intervention (I): Papaverine; topical or intravenous or intraarterial administration Comparator (C): wherever available the studies will be grouped for subgroup analysis with comparator as control or analogous other treatment modalities Outcome (O): prevention of vasospasm, intraoperative adverse effects, other adverse effects, mortality, infarct, neurological deficits, cranial nerve deficits Time frame (T): No time restriction Study design (S): RCT, Non-RCT, Clinical trial, Case series, Cohort study, Comparative study, Case reports and letter to the editor for qualitative synthesis. RCT, Non-RCT, Clinical trial, Case series, Cohort study, Comparative study for quantitative synthesis
- Study Type Included
- Inclusion: RCT, Non-RCT, Clinical trial, Case series, Cohort study, Comparative study, Case reports and letter to the editor for qualitative synthesis. RCT, Non-RCT, Clinical trial, Case series, Cohort study, Comparative study for quantitative synthesis. Exclusion: Reviews, genetic studies, animal studies
- Condition Being Studied
- Papaverine is commonly used to prevent vasospasm in aneurysmal subarachnoid haemorrhage patients. Papaverine is administered topically or intracisternal or intrarterial. The systematic review aims to evaluate the evidence on use of papaverine (topical/intraarterial) in preventing vasospasm. The review is focussed on different but related outcomes. The outcomes of interest in this study are vasospasm, mortality, adverse effects and complications.
- Participant
- Inclusion: All patients with aneurysmal subarachnoid haemorrhage receiving papaverine. Exclusion: Patients with pre-existing stroke, non-availability of data with respect to papaverine administration, use of drugs other than papaverine to prevent vasospasm. To study the adverse effect profile of topical papaverine, we will also include the case reports to appropriately identify the rare reported adverse events.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion:Topical/intracisternal/intraarterial papaverine. Exclusion: drugs other than papaverine to prevent vasospasm. Studies where some other drugs are used with papaverine where papaverine is not the primary drug to prevent vasospasm
- Comparator Control
- Wherever available control population as saline or urokinase or other drugs will be used for comparison with papaverine. Such comparison will be done as subgroup analysis
- Main Outcome
- Two most important outcomes in this review are vasospasm and adverse effects. Vasospasm is defined by clinical and radiological findings. We will discuss the differences in these definitions in our reviews. Adverse effects as outcomes are defined as unintended harmful effect arising out of direct relationship with papaverine administration. Measures of effect In this review, we will use Odd's ratio for case control studies and relative risk for cohort studies. In the aggregated case reports the measures of effect will be assessed using descriptive statistics.
- Outcome Measure
- Additional Outcome
- Additional outcomes include mortality, functional outcome and quality of life if they are reported in published literature Measures of effect In this review, we will use Odd's ratio for case control studies and relative risk for cohort studies. In the aggregated case reports the measures of effect will be assessed using descriptive statistics.
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Systematic review
- Keyword
- Humans; Intracranial Aneurysm; Papaverine; Subarachnoid Hemorrhage; Vasospasm, Intracranial
- Contact
- Rakesh Mishra [email protected]
- Organisational Affiliation
- Banaras Hindu University https://bhu.ac.in
- Funding Source
- No funding sources Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None to report
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-10-06
- Registration Date
- 2021-11-06
- Anticipated Start Date
- 2021-10-10
- Anticipated Completion Date
- 2022-04-10
- Title Cn
- 罂粟碱与动脉瘤性蛛网膜下腔出血后结局：系统评价与Meta分析
- Title En
- Papaverine and outcome following aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis
- Bilingual Status
- complete