Meta AnalysisID 3849
木瓜蛋白酶治疗慢性伤口的有效性、安全性和成本效果：一项系统评价
CRD42017079849
Is papain effective to treat chronic wounds? Is papain safe to treat chronic wounds? Is papain cost-effective to treat chronic wounds?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3849
- Evidence Id
- 12407
- Core Evidence Id
- 12407
- Source Meta Analysis Id
- 3803
- Herb2 Meta Analysis Id
- HBMA003803
- Crd Id
- CRD42017079849
- Title
- Effectiveness, safety and cost-effectiveness of papain for treating chronic wounds: a systematic review
- Review Question
- Is papain effective to treat chronic wounds? Is papain safe to treat chronic wounds? Is papain cost-effective to treat chronic wounds?
- Study Type Included
- Original published studies conducted in humans with the following types of design: 1. Randomized clinical trials; 2. Non-randomized clinical trials; 3. Prospective controlled cohort studies; 4. Economic evaluations: cost-benefit analyses, cost-utility studies, cost-effectiveness studies, cost-minimization studies and direct and/or indirect costs.
- Condition Being Studied
- Chronic wounds.
- Participant
- Adults or elderly with chronic wounds of any cause (such as pressure ulcers, venous leg ulcers, arterial ulcers, neurotrophic ulcers and foot ulcers in people with diabetes).
- Animal
- Human Disease Modelled
- Intervention
- Inclusion criteria: Papain in any concentration Exclusion criteria: Ongoing studies and study protocols.
- Comparator Control
- Placebo, standard care or alternative topical therapies.
- Main Outcome
- 1.The proportion of chronic wounds completely healed. 2.Total epithelized area at the end of the intervention. 3. Percentage of the wound area healed. Measures of effect 1.The proportion of chronic wounds completely healed will be defined as 100% epithelization or skin closure without drainage. 2.Total epithelized area at the end of the intervention will be measured in cm-squared.
- Outcome Measure
- Additional Outcome
- 1. Time to complete wound healing. 2. Wound pain. 3. Wound complications: infection, necrosis. 4. Quality of life. 5. Adverse events. 6. Cost. Measures of effect 1. Time to complete wound healing evaluated with the register of the days or weeks. 2. Wound pain (measured by any validated scale). 3. Quality of life (measured by any validated scale).
- Study Method
- Cost effectiveness, Intervention, Meta-analysis, Systematic review
- Keyword
- Chronic Disease; Cost-Benefit Analysis; Humans; Papain; Wound Healing
- Contact
- Andrea Pinto Leite Ribeiro [email protected]
- Organisational Affiliation
- University Federal Fluminense www.uff.br
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2017-10-20
- Registration Date
- 2017-12-04
- Anticipated Start Date
- 2017-11-06
- Anticipated Completion Date
- 2018-06-18
- Title Cn
- 木瓜蛋白酶治疗慢性伤口的有效性、安全性和成本效果：一项系统评价
- Title En
- Effectiveness, safety and cost-effectiveness of papain for treating chronic wounds: a systematic review
- Bilingual Status
- complete