Meta AnalysisID 3749
氧化苦参碱对人肝癌Bel-7404细胞增殖的影响：系统评价和Meta分析方案
CRD42020166497
Is oxymatrine effective on the proliferation of human liver cancer Bel-7404 cells (HLCBC)?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3749
- Evidence Id
- 12307
- Core Evidence Id
- 12307
- Source Meta Analysis Id
- 3709
- Herb2 Meta Analysis Id
- HBMA003709
- Crd Id
- CRD42020166497
- Title
- Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: a protocol of systematic review and meta-analysis
- Review Question
- Is oxymatrine effective on the proliferation of human liver cancer Bel-7404 cells (HLCBC)?
- Study Type Included
- This study will include CCSs or RCSs that assessed the effects of oxymatrine on the proliferation of HLCBC.
- Condition Being Studied
- Oxymatrine and human liver cancer Bel-7404 cells
- Participant
- This study will include HLCBC as its research targets.
- Animal
- Human Disease Modelled
- Intervention
- All studies utilized oxymatrine to manage HLCBC in the experimental group.
- Comparator Control
- All studies which used any treatments as their comparators will be included, except oxymatrine.
- Main Outcome
- Primary outcome is HLCBC proliferation, as measured by MTT assay kit. Measures of effect Not applicable
- Outcome Measure
- Additional Outcome
- Secondary outcomes are HLCBC-related genes expression, including E2F transcription factor 1 and c-myc genes, as measured by Real-time polymerase chain reaction; and HLCBC-related proteins expression, consisting of c-myc mitogen-activated protein kinase 1 and cyclin D1 expressions, as measured by immunofluorescence or western blot test. Measures of effect Not applicable
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Synthesis of qualitative studies, Systematic review
- Keyword
- Alkaloids; Cell Proliferation; Humans; Liver Neoplasms; Meta-Analysis as Topic; Quinolizines; Systematic Reviews as Topic; oxymatrine
- Contact
- Jing Li [email protected]
- Organisational Affiliation
- First Affiliated Hospital of Jiamusi University
- Funding Source
- This study was funded by Scientific Research Project of Heilongjiang Provincial Health and Health Committee (2019-308).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-01-22
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-02-29
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 氧化苦参碱对人肝癌Bel-7404细胞增殖的影响：系统评价和Meta分析方案
- Title En
- Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: a protocol of systematic review and meta-analysis
- Bilingual Status
- complete