Meta AnalysisID 3739
赖氨酰氧化酶表达在胃癌中的临床病理与预后价值：一项Meta分析和生物信息学分析
CRD42022284572
We performed a meta-analysis analysis of prospective or retrospective approaches to clarify the relationship and existed conflict of LOX expression in GC between clinicopathological parameters and prognosis.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3739
- Evidence Id
- 12297
- Core Evidence Id
- 12297
- Source Meta Analysis Id
- 3700
- Herb2 Meta Analysis Id
- HBMA003700
- Crd Id
- CRD42022284572
- Title
- Clinicopathological and prognostic value of Lysyl oxidase expression in gastric cancer: a meta-analysis and bioinformatics analysis
- Review Question
- We performed a meta-analysis analysis of prospective or retrospective approaches to clarify the relationship and existed conflict of LOX expression in GC between clinicopathological parameters and prognosis.
- Study Type Included
- Randomized controlled trials, prospective or retrospective approaches, and all other quantitative research designs
- Condition Being Studied
- Gastric cancer (GC) is one of the most commonly occurring cancerous tumors of the gastrointestinal tract, ranking fifth in incidence rate and fourth in terms of death among cancers. Each year, over 1 million new cases are diagnosed, and roughly 783, 000 people die. GC have become a major health burden throughout the world. Despite notable improvements in the early detection, staging system, and treatment of GC, the 5-year overall survival (OS) rate remains about 40%. Patients with stage II, III, and IV GC, in particular, have a 5-year survival rate of nearly 31%, 13%, and 3%, respectively. The high mortality rate is mostly caused by a lack of cognition of cancer invasion and metastasis. There is an urgent need to regard cancer progression as a continuous process that is dependent on these intricate networks of both the immediate tumor microenvironment (TME) and the extended TME. The continual evolution of the TME through the various clinical phases occurred in lockstep with cancer cell proliferation and invasion. Therefore, to reduce the high mortality and recurrence rates associated with GC, it is critical and urgent to find innovative biomarkers for early diagnosis and prognosis, as well as new therapeutic targets in TME.
- Participant
- patients with gastric cancer.
- Animal
- Human Disease Modelled
- Intervention
- Lysyl oxidase with high expression
- Comparator Control
- Lysyl oxidase with low expression
- Main Outcome
- To clarify the relationship and existed conflict of LOX expression and methylation in GC between clinicopathological parameters and prognosis. For dichotomous variables including gender, Lauren classification, differentiation, depth of invasion, lymph node metastases, and tumor metastasis, the odds ratio (OR) and 95% confidence interval (CI) were adopted. Measures of effect odds ratios
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Biomarkers, Tumor; Computational Biology; Humans; Prognosis; Protein-Lysine 6-Oxidase; Stomach Neoplasms
- Contact
- Zirui Jia [email protected]
- Organisational Affiliation
- Dalian Central Hospital Affiliated to Dalian Medical University
- Funding Source
- This work was supported by grants from National Natural Science Foundation of China (grant number 81700465), the Natural Science Foundation of Liaoning Province, China (No. 2019-BS-059) and High-level Talents Innovation Plan of Dalian, China (No.2018RQ27).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2022-03-28
- Registration Date
- 2022-04-28
- Anticipated Start Date
- 2022-02-10
- Anticipated Completion Date
- 2022-05-01
- Title Cn
- 赖氨酰氧化酶表达在胃癌中的临床病理与预后价值：一项Meta分析和生物信息学分析
- Title En
- Clinicopathological and prognostic value of Lysyl oxidase expression in gastric cancer: a meta-analysis and bioinformatics analysis
- Bilingual Status
- complete