Meta AnalysisID 3734
香芹酚和百里香酚的抗肿瘤活性：一项系统评价[暂定标题]
CRD42020176736
Do carvacrol and thymol have any anti-tumor effect on cancer cells and in animal experiments? Context and rationale Cancer is one of the main public health problems in the world and appears among the top four causes of p
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Record Fields
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- Meta Analysis Id
- 3734
- Evidence Id
- 12292
- Core Evidence Id
- 12292
- Source Meta Analysis Id
- 3695
- Herb2 Meta Analysis Id
- HBMA003695
- Crd Id
- CRD42020176736
- Title
- Antitumor activity of carvacrol and thymol - a systematic review [provisional title]
- Review Question
- Do carvacrol and thymol have any anti-tumor effect on cancer cells and in animal experiments? Context and rationale Cancer is one of the main public health problems in the world and appears among the top four causes of premature death (before age 70) in most countries. Its incidence and mortality are increasing worldwide due to aging and population growth, as well as changes in the distribution and prevalence of socioeconomic cancer risk factors (INCA, 2020). Currently, cancer treatment includes chemotherapy, radiation therapy and / or surgical procedures, which in turn have many side effects. Therefore, active products derived from medicinal plants have been used as a safe and effective alternative, which can also be used for the prevention and treatment of certain types of cancer. In this context, the objective of this review is to systematically review whether carvacrol and thymol, natural components of the essential oils of thyme, oregano, rosemary and laurel, are promising alternatives for anticancer agents through surveys of in-vivo and in- vitro.
- Study Type Included
- Inclusion criteria: Experimental studies (pre-clinical in vitro or in vivo) Exclusion criteria: Clinical studies
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Laboratory animal with disease (Male Swiss mice, Female Swiss mice, Male Sprague-Dawley rats, Adult male CF No 1 mice, Male Strain CF-1 mice, Male ICR mice, Male Lewis rats, Male Wistar rats, Male BALB/c mice) and in-vitro studies for antitumor effect (cell viability, apoptosis). Exclusion criteria: Animals with other associated diseases, Experimental animals that used anti-inflammatory drugs
- Human Disease Modelled
- Cancer
- Intervention
- Inclusion criteria: Monoterpenes (carvacrol and thymol) independently of timing of treatment or obtaining Exclusion criteria: Studies that evaluated essential oils in general, without studying carvacrol and/or thymol separately.
- Comparator Control
- Inclusion criteria: No treatment or placebo Exclusion criteria: None
- Main Outcome
- Outcome Measure
- Inclusion criteria: Behavioral, biochemical, molecular and histology Exclusion criteria: Effects not directly related to cancer involvement: Antibacterial effects, anti-inflammatory effects, antioxidants, antiangiogenics, among others
- Additional Outcome
- Study Method
- Keyword
- Animals; Monoterpenes; Thymol; carvacrol
- Contact
- Laeza Alves Sampaio [email protected]
- Organisational Affiliation
- Universidade Federal de Sergipe http://www.ufs.br/
- Funding Source
- None Grant number(s) None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-04-06
- Registration Date
- 2020-05-22
- Anticipated Start Date
- 2020-05-30
- Anticipated Completion Date
- 2020-12-07
- Title Cn
- 香芹酚和百里香酚的抗肿瘤活性：一项系统评价[暂定标题]
- Title En
- Antitumor activity of carvacrol and thymol - a systematic review [provisional title]
- Bilingual Status
- complete