Meta AnalysisID 3731
橄榄叶橄榄苦苷在代谢中的作用：随机对照试验的系统评价
CRD42022375615
Does oral consumption of oleuropein or olive leaf in adults or elderly cause effects on blood glucose, plasma lipids or inflammatory markers in randomized controlled trials?P - Adults or elderly (+18) I - Olive leaf or o
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3731
- Evidence Id
- 12289
- Core Evidence Id
- 12289
- Source Meta Analysis Id
- 3692
- Herb2 Meta Analysis Id
- HBMA003692
- Crd Id
- CRD42022375615
- Title
- Olive leaf oleuropein effects in metabolism: a systematic review of randomized controlled trials
- Review Question
- Does oral consumption of oleuropein or olive leaf in adults or elderly cause effects on blood glucose, plasma lipids or inflammatory markers in randomized controlled trials?P - Adults or elderly (+18) I - Olive leaf or oleuropein via oral C - Placebo O - Blood glucose, plasma lipids and inflammatory markers S - Randomized controlled trials
- Study Type Included
- Only Randomized controlled trials and crossover of controlled trials will be included. Furthermore, articles in English and Portuguese that contain an abstract and full text will be included. Other types of primary studies and secondary studies (e.g. systematic review) will be excluded. Articles in another language and that do not contain an abstract or full text will be excluded.
- Condition Being Studied
- Studies that assess specific health conditions will be evaluated. This means studies that assess the improvement in the performance of one or more health markers associated with the consumption of oleuropein or OLE. Therefore, studies that evaluate the improvement in blood glucose levels (pre and post prandial glucose and insulin), plasma lipids (LDL, HDL and total cholesterol) and inflammatory markers (cytokine production).
- Participant
- Population are adults and elderly, over 18 years old, of both sexes (women or men) with or without previous pathologies. If the person is under the age of 18, it will be excluded from the review. Studies with people outside the age group in the same group of people within the age group will also be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The intervention was established as consumption of oleuropein or olive leaf extract, in any form of manipulation, by the oral route of administration.
- Comparator Control
- The control group will be the untreated group (placebo) or the group that received the gold standard treatment depending on the study design.
- Main Outcome
- The primary outcomes that will be evaluated are effects on blood glucose (pre and post prandial blood glucose and insulin levels); plasma lipid levels (LDL, HDL and total cholesterol) and inflammatory markers (cytokine production (IL-6; IL-8 and TNF-alpha). Measures of effect None
- Outcome Measure
- Additional Outcome
- None Measures of effect none
- Study Method
- Systematic review
- Keyword
- Adult; Aged; Blood Glucose; Classification; Humans; Lipids; Olea; Plant Leaves; Randomized Controlled Trials as Topic; oleuropein
- Contact
- Rafaella Menezes [email protected]
- Organisational Affiliation
- UFCSPA
- Funding Source
- This project has partial funding from the Federal University of Health Sciences of Porto Alegre, with researchers scholarships. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-17
- Registration Date
- 2022-11-28
- Anticipated Start Date
- 2022-11-14
- Anticipated Completion Date
- 2023-09-14
- Title Cn
- 橄榄叶橄榄苦苷在代谢中的作用：随机对照试验的系统评价
- Title En
- Olive leaf oleuropein effects in metabolism: a systematic review of randomized controlled trials
- Bilingual Status
- complete