Meta AnalysisID 3721
亚洲人群丙氨酸氨基转移酶水平上限评估
CRD42019135468
What is the upper limit of normal alanine transaminase (ALT) in Asians?
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Record Fields
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- Meta Analysis Id
- 3721
- Evidence Id
- 12279
- Core Evidence Id
- 12279
- Source Meta Analysis Id
- 3679
- Herb2 Meta Analysis Id
- HBMA003679
- Crd Id
- CRD42019135468
- Title
- Evaluating the upper limit of alanine transaminase levels in Asians
- Review Question
- What is the upper limit of normal alanine transaminase (ALT) in Asians?
- Study Type Included
- Cross-sectional studies or cohort studies that present ALT values for patients in whom NAFLD, viral hepatitis and alcoholic liver disease have been excluded. Inclusion criteria 1) Adult patients (aged>=18) in Asia; 2) Studies which have included ALT readings; 3) Studies which have excluded NAFLD by ultrasound; 4) Studies which excluded viral hepatitis and significant alcohol consumption. Exclusion criteria 1) Irrelevant: articles that do not match the inclusion criteria.
- Condition Being Studied
- Serum ALT levels are commonly used to evaluate for the presence of liver disease. The conventionally used upper limit of normal is 40 IU/L, based on data from the 1980s. This was established prior to the onset of hepatitis C testing, and without the exclusion of non-alcoholic fatty liver disease (NAFLD). The true upper limit of normal of ALT is yet to be defined in Asians.
- Participant
- Adult patients (aged>=18) in Asia with available ALT values, and in whom NAFLD, viral hepatitis and alcoholic liver disease have been excluded.
- Animal
- Human Disease Modelled
- Intervention
- Upper limit evaluation for alanine transaminase levels in Asians.
- Comparator Control
- Not applicable.
- Main Outcome
- Pooled means and upper limits of normal ALT values in Asians without NAFLD, viral hepatitis and alcoholic liver disease. Measures of effect As given in the source documents.
- Outcome Measure
- Additional Outcome
- We plan to investigate the pooled mean and upper limit of normal ALT values in the following subgroups: obese, male, female, diabetic patients. Measures of effect As given in the source documents.
- Study Method
- Diagnostic, Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Alanine Transaminase; Asia; Asian Continental Ancestry Group; Biomarkers; Diagnostic Techniques, Digestive System; Humans; Liver; Reference Standards; Reference Values
- Contact
- Daniel Huang [email protected]
- Organisational Affiliation
- National University Health System
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Singapore, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-05-31
- Registration Date
- 2019-08-12
- Anticipated Start Date
- 2019-03-05
- Anticipated Completion Date
- 2019-09-24
- Title Cn
- 亚洲人群丙氨酸氨基转移酶水平上限评估
- Title En
- Evaluating the upper limit of alanine transaminase levels in Asians
- Bilingual Status
- complete