Meta AnalysisID 3693
去甲肾上腺素与去氧肾上腺素用于腰麻下剖宫产术中产妇低血压的管理：一项系统评价和Meta分析
CRD42018111731
In recent years, the application of norepinephrine to manage maternal hypotension is explored by various studies in women undergoing cesarean delivery with spinal anesthesia. This systematic review and meta-analysis comp
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3693
- Evidence Id
- 12251
- Core Evidence Id
- 12251
- Source Meta Analysis Id
- 3651
- Herb2 Meta Analysis Id
- HBMA003651
- Crd Id
- CRD42018111731
- Title
- Norepinephrine versus phenylephrine for management of maternal hypotension during cesarean delivery with spinal anesthesia: a systematic review and meta-analysis
- Review Question
- In recent years, the application of norepinephrine to manage maternal hypotension is explored by various studies in women undergoing cesarean delivery with spinal anesthesia. This systematic review and meta-analysis compared the efficacy and safety of norepinephrine versus phenylephrine for the prevention and treatment of maternal hypotension with available randomized controlled trials (RCTs).
- Study Type Included
- Randomized controlled trials (RCTs).
- Condition Being Studied
- Maternal hypotension is a physiological response during cesarean delivery with spinal anesthesia, significantly contributing to adverse maternal outcomes such as nausea, vomiting, dizziness, and even cardiovascular collapse. Besides, compromised placental perfusion raises the concerns of fetal acidosis, hypoxia, and even postnatal neurological injury. Thus, effective prevention or treatment of maternal hypotension is of great clinical significance.
- Participant
- Full reports of randomized controlled trials that evaluated the effect of norepinephrine versus phenylephrine for maternal hypotension during cesarean section with spinal anesthesia were included in this review.
- Animal
- Human Disease Modelled
- Intervention
- We considered any trials of norepinephrine and phenylephrine administered before, during, or immediately after the induction of spinal anesthesia, regardless of dose or mode of administration.
- Comparator Control
- We considered any trials of norepinephrine and phenylephrine administered before, during, or immediately after the induction of spinal anesthesia, regardless of dose or mode of administration.
- Main Outcome
- Incidence of hypotension, hypertension, bradycardia, tachycardia, maternal side effects including nausea, vomiting, dizziness, as well as neonatal outcomes.
- Outcome Measure
- Additional Outcome
- Umbilical arterial pH values, venous pH values, neonatal Apgar scores.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Female; Humans; Hypotension; Norepinephrine; Phenylephrine; Pregnancy
- Contact
- Xian Wang [email protected]
- Organisational Affiliation
- Department of Anesthesiology, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing,China
- Funding Source
- This study is supported by Young Talents Project of Maternal and Child Health Care in Jiangsu Province (FRC201787).
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-10-05
- Registration Date
- 2018-11-22
- Anticipated Start Date
- 2018-11-10
- Anticipated Completion Date
- 2019-01-01
- Title Cn
- 去甲肾上腺素与去氧肾上腺素用于腰麻下剖宫产术中产妇低血压的管理：一项系统评价和Meta分析
- Title En
- Norepinephrine versus phenylephrine for management of maternal hypotension during cesarean delivery with spinal anesthesia: a systematic review and meta-analysis
- Bilingual Status
- complete