Meta AnalysisID 3685
氨茶碱预防和/或治疗硬脊膜穿刺后头痛：一项系统评价与Meta分析研究方案
CRD42020211990
Primary objective: Investigating the effect of aminophylline on prevention and/or treatment of post-dural puncture headache is the primary target of this study. Secondary objectives: 1- Estimating the effect of aminophyl
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3685
- Evidence Id
- 12243
- Core Evidence Id
- 12243
- Source Meta Analysis Id
- 3644
- Herb2 Meta Analysis Id
- HBMA003644
- Crd Id
- CRD42020211990
- Title
- Aminophylline for prevention and/or Treatment of Post-dural Puncture Headache: A Systematic Review and Meta-Analysis, Study Protocol
- Review Question
- Primary objective: Investigating the effect of aminophylline on prevention and/or treatment of post-dural puncture headache is the primary target of this study. Secondary objectives: 1- Estimating the effect of aminophylline on prevention and/or treatment of post-dural puncture headache by age group. 2- Estimating the effect of aminophylline on prevention and/or treatment of post-dural puncture headache by gender. 3- Evaluating potential heterogeneity and finding its root causes.
- Study Type Included
- All the clinical trials that have appropriately (according to an acceptable description) examined the preventive and/or therapeutic effects of aminophylline on post-dural puncture headache would be selected to be analyzed in this study. This study will not contain case reports, case series, observational studies, non-randomized trials, cross sectional studies, review articles, and protocol papers.
- Condition Being Studied
- Post-dural puncture headache, which is defined as a clinical manifestations of lumbar puncture, will be considered as the outcome of this study.
- Participant
- All the participants (male, female or both) undergoing lumbar puncture will be considered in this study.
- Animal
- Human Disease Modelled
- Intervention
- To be analyzed in this study, interventions must aim to prevent and/or ameliorate post-dural puncture headache using intravenously or orally administered aminophylline.
- Comparator Control
- Comparator arms of the included studies might be groups of participants that did not administer aminophylline to prevent and/or ameliorate post-dural puncture headache.
- Main Outcome
- The assessment of post-dural puncture headache will be the outcome measure of this study. Measures of effect The effect size is the Standardized Mean Difference according to means of pain scores before and after the intervention.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Aminophylline; Blood Patch, Epidural; Humans; Meta-Analysis as Topic; Post-Dural Puncture Headache; Systematic Reviews as Topic
- Contact
- Ali Reza Safarpour [email protected]
- Organisational Affiliation
- Shiraz University of Medical Sciences https://sums.ac.ir/
- Funding Source
- Vice-Chancellor for Research, Shiraz University of Medical Sciences, Grant Number: 21331
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-07
- Registration Date
- 2020-11-06
- Anticipated Start Date
- 2020-10-30
- Anticipated Completion Date
- 2022-07-31
- Title Cn
- 氨茶碱预防和/或治疗硬脊膜穿刺后头痛：一项系统评价与Meta分析研究方案
- Title En
- Aminophylline for prevention and/or Treatment of Post-dural Puncture Headache: A Systematic Review and Meta-Analysis, Study Protocol
- Bilingual Status
- complete