Meta AnalysisID 3676
硝苯地平治疗妊娠期高血压危象的安全性和有效性：一项系统评价与Meta分析
CRD42021231820
What is the safety and efficacy of Nifedipine compared with all other antihypertensives in the management of hypertensive crisis in pregnancy?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 3676
- Evidence Id
- 12234
- Core Evidence Id
- 12234
- Source Meta Analysis Id
- 3635
- Herb2 Meta Analysis Id
- HBMA003635
- Crd Id
- CRD42021231820
- Title
- Safety and efficacy of Nifedipine in the management of hypertensive crisis in pregnancy: A systematic review and Meta-analysis.
- Review Question
- What is the safety and efficacy of Nifedipine compared with all other antihypertensives in the management of hypertensive crisis in pregnancy?
- Study Type Included
- Will include randomized controlled trials (RCTs), regardless of language or publication status.
- Condition Being Studied
- Hypertension is the most common disorder in pregnancy. The hypertensive disorders of pregnancy leads to maternal and neonatal morbidity and mortality. The drugs mostly used for this condition are labetalol, nifedipine and hydralazine. Nifedipine is a calcium channel blocker which is used as a safer drug in hypertensive crisis in pregnancy.
- Participant
- We will include women who are pregnant of aged 18 years and more diagnosed with hypertension. We will include studies compare directly nifedipine with other antihypertensive drugs on maternal and neonatal outcomes in pregnant patients with hypertension. We will exclude studies which compare nifedipine combinations with other antihypertensives for management of hypertension in pregnancy.
- Animal
- Human Disease Modelled
- Intervention
- We will include studies used Nifedipine alone given for management of hypertension in pregnancy.
- Comparator Control
- All other antihypertensives used in the management of hypertensive crisis in pregnancy.
- Main Outcome
- a. Time needed to achieve target BP b. Dose needed to achieve target BP c. Apgar score d. Mode of delivery Measures of effect Relative risk, Odds ratio
- Outcome Measure
- Additional Outcome
- a. Maternal outcomes i. HELLP syndrome ii. Hypotension iii. Pulmonary oedema iv. Maternal death v. Placental abruption vi. Maternal tachycardia b. Neonatal outcomes i. Birth weight ii. NICU admission iii. Neonatal mortality iv. Intrauterine death v. Fetal heart rate abnormalities Measures of effect Relative risk, Odds ratio
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Antihypertensive Agents; Female; Humans; Hypertension; Nifedipine; Pregnancy
- Contact
- Ramu Adela [email protected]
- Organisational Affiliation
- NIPER Guwahati
- Funding Source
- no
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-01-18
- Registration Date
- 2021-02-18
- Anticipated Start Date
- 2020-12-02
- Anticipated Completion Date
- 2021-04-10
- Title Cn
- 硝苯地平治疗妊娠期高血压危象的安全性和有效性：一项系统评价与Meta分析
- Title En
- Safety and efficacy of Nifedipine in the management of hypertensive crisis in pregnancy: A systematic review and Meta-analysis.
- Bilingual Status
- complete